Roles of Histone Deacetylase 4 in the Inflammatory and Metabolic Processes [PDF]
Diabetes & Metabolism JournalHistone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins ...
Hyunju Kang +3 more
doaj +5 more sources
The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development [PDF]
Bone and Joint Research, 2020 Chondrocyte hypertrophy represents a crucial turning point during endochondral bone development. This process is tightly regulated by various factors, constituting a regulatory network that maintains normal bone development. Histone deacetylase 4 (HDAC4)
Xiao-Chun Wei, Lei Wei
exaly +3 more sources
Structure-Based Identification of Novel Histone Deacetylase 4 (HDAC4) Inhibitors [PDF]
Pharmaceuticals, 2022 Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. However, engineering specificity is an important goal.
Rupesh Agarwal +5 more
doaj +4 more sources
Irisin Ameliorates Hypoxia/Reoxygenation-Induced Injury through Modulation of Histone Deacetylase 4. [PDF]
PLoS ONE, 2016 Irisin is a recently identified myokine which brings increases in energy expenditure and contributes to the beneficial effects of exercise through the browning of white adipose tissues. However, its effects in the heart remains unknown. This study sought
Yu Tina Zhao +5 more
doaj +3 more sources
The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy. [PDF]
J Inflamm Res, 2022 Purpose To determine the role of histone deacetylase 4 (HDAC4)-controlled chondrocyte hypertrophy in the onset and development of age-related osteoarthritis (OA). Methods Morphological analysis of human knee cartilages was performed to observe structural
Dong Z +10 more
europepmc +2 more sources
Inhibitory Effects of Ginsenoside Compound K on Lipopolysaccharide-Stimulated Inflammatory Responses in Macrophages by Regulating Sirtuin 1 and Histone Deacetylase 4. [PDF]
Nutrients, 2023 Inflammation, an innate immune response mediated by macrophages, has been a hallmark leading to the pathophysiology of diseases. In this study, we examined the inhibitory effects of ginsenoside compound K (CK) on lipopolysaccharide (LPS)-induced ...
Kang H, Kim S, Lee JY, Kim B.
europepmc +2 more sources
Histone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblasts. [PDF]
Aging (Albany NY), 2022 Histone deacetylases (HDACs) remove acetyl groups from lysine chains on histones and other proteins and play a crucial role in epigenetic regulation and aging.
Lee Y +7 more
europepmc +2 more sources
Clinical role of serum histone deacetylase 4 measurement in acute ischemic stroke: Relation to disease risk, severity, and prognosis. [PDF]
J Clin Lab Anal, 2022 Histone deacetylase 4 (HDAC4) is engaged in the pathophysiology of acute ischemic stroke (AIS) through modulating atherosclerosis, inflammation and neurocyte death. This study aimed to investigate the clinical role of HDAC4 in AIS.
Wang M, Pang X, Lu H, Wang X.
europepmc +2 more sources
Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα sumoylation. [PDF]
J Mol Cell Biol, 2020 Protein modification by small ubiquitin-like modifier (SUMO) is an important regulatory mechanism for multiple cellular processes. Although the canonical pathway involving the ubiquitylation or phosphorylation of IκBα has been well characterized, little ...
Yang Q +8 more
europepmc +2 more sources
Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells [PDF]
Brain Sciences, 2023 (1) Background: Parkinson’s disease (PD) is the most common movement disorder. Imbalanced protein homeostasis and α-syn aggregation are involved in PD pathogenesis.
Luxi Wang +10 more
doaj +2 more sources