Results 41 to 50 of about 167,650 (273)
Scientia Pharmaceutica, 2019 Histone deacetylase inhibitors with zinc binding groups often exhibit drawbacks like non-selectivity or toxic effects. Thus, there are continuous efforts to modify the currently available inhibitors or to discover new derivatives to overcome these ...
Duraid H. Al-Amily +1 more
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Histone deacetylase inhibitors
Journal of Education, Health and Sport, 2020 The human genome is contained in chromatin, which is a complex macromolecular complex. It is made of DNA, histones and non-histone proteins. The structure of chromatin and the process of its rearrangement regulate the process of transcription, and hence ...
Marzena Baran +2 more
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Histone deacetylase 4 alters cartilage homeostasis in human osteoarthritis [PDF]
BMC Musculoskeletal Disorders, 2014 Osteoarthritis (OA) is the most common degenerative joint disorder, and a major cause of pain and disability among the elderly. Histone deacetylase 4 (HDAC4) has been shown to be a key regulator of chondrocyte hypertrophy during skeletogenesis. The aims of present study were to investigate the expression of HDAC4 in normal and OA cartilage and its ...
Lu, Jingwei +4 more
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Translational Oncology, 2016 Background: The current chemotherapeutic outcomes for hepatocellular carcinoma (HCC) are not encouraging, and long-term survival of this patient group remains poor.
Jing Liu +9 more
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Conditional deletion of HDAC4 from collagen type 2α1-expressing cells increases angiogenesis in vivo
Molecular Medicine, 2020 Background HDAC4 is a key regulator of chondrocyte hypertrophy and skeletal development, but it is not clear whether the increase in vascular invasion at growth plates is related to HDAC4 expression.
Lilan Gao +5 more
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Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation
Haematologica, 2010 Background The clinical use of chromatin-modulating drugs, such as histone deacetylase inhibitors, for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last few years.
Marije Bartels +4 more
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Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans
npj Microgravity, 2021 Epigenetic changes during long-term spaceflight are beginning to be studied by NASA’s twin astronauts and other model organisms. Here, we evaluate the epigenetic regulation of gene expression in space-flown C.
Atsushi Higashitani +8 more
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Caspase-mediated Specific Cleavage of Human Histone Deacetylase 4 [PDF]
Journal of Biological Chemistry, 2004 Histone deacetylase 4 (HDAC4) is a class II HDAC implicated in controlling gene expression important for diverse cellular functions, but little is known about how its expression and stability are regulated. We report here that this deacetylase is unusually unstable, with a half-life of less than 8 h.
Fang, Liu +3 more
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Frontiers in Molecular Neuroscience, 2017 The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer’s disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain.
Jingzhu Zhang +8 more
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Valproate alters dopamine signaling in association with induction of Par-4 protein expression. [PDF]
PLoS ONE, 2012 Chromatin remodeling through histone modifications has emerged as a key mechanism in the pathophysiology of psychiatric disorders. Valproate (VPA), a first-line medication for bipolar disorder, is known to have histone deacetylase (HDAC) inhibitor ...
Saebom Lee +7 more
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