Results 51 to 60 of about 167,650 (273)
Sci, 2022 Artesunate (ART), a plant based semi-synthetic antimalarial drug, is emerging as a new class of effective cancer chemotherapeutics. However, the dosage of ART required to have an anti-cancer effect on cancer cells is greater than that needed to ...
Asif Raza +3 more
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Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response [PDF]
The Journal of Cell Biology, 2003 Anumber of proteins are recruited to nuclear foci upon exposure to double-strand DNA damage, including 53BP1 and Rad51, but the precise role of these DNA damage–induced foci remain unclear. Here we show in a variety of human cell lines that histone deacetylase (HDAC) 4 is recruited to foci with kinetics similar to, and colocalizes with, 53BP1 after ...
Kao, G +5 more
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Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy. [PDF]
Kidney International, 2014 Studies have highlighted the importance of histone deacetylase (HDAC)-mediated epigenetic processes in the development of diabetic complications. Inhibitors of HDAC are a novel class of therapeutic agents in diabetic nephropathy, but currently available inhibitors are mostly nonselective inhibit multiple HDACs, and different HDACs serve very distinct ...
Xiao-Jie Wang +15 more
semanticscholar +3 more sources
Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. [PDF]
PLoS Genetics, 2011 Elevation of the second messenger cGMP by nitric oxide (NO) activates the cGMP-dependent protein kinase PKG, which is key in regulating cardiovascular, intestinal, and neuronal functions in mammals.
Yan Hao +10 more
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Regulation of Histone Deacetylase 4 Expression by the SP Family of Transcription Factors [PDF]
Molecular Biology of the Cell, 2006 Histone deacetylases mediate critical cellular functions but relatively little is known about mechanisms controlling their expression, including expression of HDAC4, a class II HDAC implicated in the modulation of cellular differentiation and viability.
Fang, Liu +6 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2016 Histone acetylation is a major mechanism of chromatin remodeling, contributing to epigenetic regulation of gene transcription. Histone deacetylases (HDACs) are involved in both physiological and pathological conditions by regulating the status of histone
Yili Wu +5 more
doaj +1 more source
Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death [PDF]
The Journal of Neuroscience, 2005 Histone deacetylase 4 (HDAC4) undergoes signal-dependent shuttling between the cytoplasm and nucleus, which is regulated in part by calcium/calmodulin-dependent kinase (CaMK)-mediated phosphorylation. Here, we report that HDAC4 intracellular trafficking is important in regulating neuronal cell death.
Timothy A, Bolger, Tso-Pang, Yao
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Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions. [PDF]
PLoS ONE, 2009 Histone deacetylase inhibitors (HDACi) have demonstrated promising therapeutic potential in clinical trials for hematological malignancies. HDACi, such as SAHA/Vorinostat, Trichostatin A, and MS-275 were found to induce apoptosis of leukemic blasts ...
Bérengère Vire +5 more
doaj +1 more source
An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation [PDF]
The Journal of Neuroscience, 2012 Histone deacetylases (HDACs), a family of enzymes involved in epigenetic regulation, have been implicated in the control of synaptic plasticity, as well as learning and memory. Previous work has demonstrated administration of pharmacological HDAC inhibitors, primarily those targeted to class I HDACs, enhance learning and memory as well as long-term ...
Mi-Sung, Kim +7 more
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Rapamycin attenuates ioversol-induced acute kidney injury in rat models [PDF]
Jichu yixue yu linchuangObjective To investigate the role of autophagy in contrast-induced acute kidney injury (CI-AKI) in rats and to explore its possible mechanism. Methods SD rats were randomly divided into control group, acute kidney injury model group (intravenous ...
LI Qingju, YU Ran, CHEN Jiajia, CHEN Haoyu, SONG Jian, WANG Wanpeng
doaj +1 more source