Results 71 to 80 of about 167,650 (273)
Experimental and Molecular Medicine, 2019 Aortic valve calcification develops in patients with chronic kidney disease who have calcium and phosphate metabolic disorders and poor prognoses. There is no effective treatment except valve replacement. However, metabolic disorders put patients at high
Jia Gu +11 more
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Overexpression of histone deacetylase 4 inhibits proliferation and invasion of colorectal cancer cells [PDF]
Jichu yixue yu linchuangObjective To investigate the regulatory role of histone deacetylase 4(HDAC4) overexpression in the proliferation and invasion of human colorectal cancer (CRC) cells.
LIU Huoxi, HUANG Botian, ZHAO Yuntao, ZHANG Jiayang, WU Wenmei
doaj +1 more source
Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. [PDF]
PLoS ONE, 2009 Enzyme-catalyzed, post-translational modifications of core histones have been implicated in the complex changes in gene expression that drive early mammalian development.
Matthew D VerMilyea +2 more
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Molecules, 2022 Twenty newly synthesized derivatives of [6]-shogaol (4) were tested for inhibitory activity against histone deacetylases. All derivatives showed moderate to good histone deacetylase inhibition at 100 µM with a slightly lower potency than the lead ...
Chanokbhorn Phaosiri +6 more
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FEBS Open Bio, 2018 High mobility group box 1 (HMGB1) has been proposed as crucial in the pathogenesis of many diseases including sepsis. Acetylation of HMGB1 prevents its entry into the nucleus and leads to its secretion from the cell where it can trigger inflammation.
E. Park, Young Min Kim, H. Kim, K. Chang
semanticscholar +1 more source
FOXP3 Up-regulates p21 Expression by Site-Specific Inhibition of Histone Deacetylase 2/Histone Deacetylase 4 Association to the Locus [PDF]
Cancer Research, 2009 Abstract p21 loss has been implicated in conferring oncogenic activity to known tumor suppressor gene KLF4 and cancer drug tamoxifen. Regulators of p21, therefore, play critical roles in tumorigenesis. Here, we report that X-linked tumor suppressor FOXP3 is essential for p21 expression in normal epithelia and that lack of FOXP3 is ...
Runhua, Liu +6 more
openaire +2 more sources
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
Cell Death and Disease, 2023 Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood.
Sheree D. Martin +15 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
International Journal of Molecular Medicine, 2018 Interleukin-1β (IL-1β)-induced inflammatory response is associated with osteoarthritis (OA) and its development. Histone deacetylase (HDAC) may be involved in regulating this pathogenesis, but the mechanism has yet to be elucidated.
Pengcheng Wang +7 more
semanticscholar +1 more source