Results 81 to 90 of about 167,650 (273)

Dephosphorylation and Caspase Processing Generate Distinct Nuclear Pools of Histone Deacetylase 4 [PDF]

Molecular and Cellular Biology, 2007
From the nucleus, histone deacetylase 4 (HDAC4) regulates a variety of cellular processes, including growth, differentiation, and survival, by orchestrating transcriptional changes. Extracellular signals control its repressive influence mostly through regulating its nuclear-cytoplasmic shuttling.
PARONI, Gabriela, FONTANINI, Alessandra, CERNOTTA, Nadia, FOTI, Carmela, GUPTA M. P, YANG X. J, FASINO, Dario, BRANCOLINI, Claudio   +7 more
openaire   +3 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The cartilage specific microRNA‐140 targets histone deacetylase 4 in mouse cells [PDF]

FEBS Letters, 2006
MicroRNAs (miRNA) are short RNA molecules regulating the expression of specific mRNAs. We investigated the expression pattern and potential targets of mouse miR‐140 and found that miR‐140 is specifically expressed in cartilage tissues of mouse embryos during both long and flat bone development.
Tuddenham, Lee, Wheeler, Guy, Ntouniafousara, Sofia, Waters, Jasmine, Hajihosseini, Mohammad, Clark, Ian, Dalmay, Tamas   +6 more
openaire   +3 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation [PDF]

Oncogene, 2011
The transcriptional activity of the androgen receptor (AR) is regulated by both ligand binding and post-translational modifications, including acetylation and small ubiquitin-like modifier (SUMO)ylation. Histone deacetylases (HDACs) are known to catalyze the removal of acetyl groups from both histones and non-histone proteins.
Yang, Yonghua, Tse, Anfernee Kai-Wing, Li, Pengfei, Ma, Qiuping, Xiang, Shengyan, Nicosia, Santo V., Seto, Edward, Zhang, Xiaohong, Bai, Wenlong   +8 more
openaire   +2 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

4-Phenylbutyric acid activates an NF-κB-Egr-1 axis to control myoblast proliferation and ECM gene expression

iScience
Summary: Myogenic progression is tightly controlled by epigenetic mechanisms. Here, we demonstrate that the histone deacetylase inhibitor 4-phenylbutyric acid (4-PBA) selectively promotes myoblast proliferation without inducing myotube differentiation ...
Kana Tominaga, Naoomi Tominaga
doaj   +1 more source

Sulforaphane absorption and histone deacetylase activity following single dosing of broccoli sprout supplement in normal dogs

Veterinary Medicine and Science, 2018
The role of epigenetic alterations during cancer has gained increasing attention and has resulted in a paradigm shift in our understanding of mechanisms leading to cancer susceptibility.
Kaitlin M. Curran, Shay Bracha, Carmen P. Wong, Laura M. Beaver, Jan F. Stevens, Emily Ho   +5 more
doaj   +1 more source

Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4

Oncology Research, 2017
miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact function in OS cells remain unknown. Herein,
Qian-Ren Xiao, Lu Huang, Zhong-Zu Zhang, Xiang Chen, Jiaquan Luo, Zhan-Min Zhang, Shao-Qing Chen, Yong Shu, Zhimin Han, K. Cao   +9 more
semanticscholar   +1 more source