Results 31 to 40 of about 167,650 (273)

4-Hexylresorcinol Inhibits Class I Histone Deacetylases in Human Umbilical Cord Endothelial Cells

Applied Sciences, 2021
Histone deacetylases (HDACs) are key enzymes for post-translational modification and influence on various cellular activities. Thus, HDACs are associated with many diseases and their inhibitors have clinical significance.
Jwa-Young Kim, Hae-Yong Kweon, Dae-Won Kim, Je-Yong Choi, Seong-Gon Kim   +4 more
doaj   +1 more source

Histone deacetylase 4 deletion broadly affects cardiac epigenetic repression and regulates transcriptional susceptibility via H3K9 methylation.

Journal of Molecular and Cellular Cardiology, 2021
Histone deacetylase 4 (HDAC4) is a member of class IIa histone deacetylases (class IIa HDACs) and is believed to possess a low intrinsic deacetylase activity.
D. Finke, L. Schanze, F. Schreiter, M. Kreusser, H. Katus, J. Backs, L. Lehmann   +6 more
semanticscholar   +1 more source

The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program

Life Science Alliance, 2022
The MLL3/4 histone methyltransferase complexes and the histone deacetylase complex MiDAC regulate the histone mark H4K20ac to calibrate gene expression of a common set of target genes. The mitotic deacetylase complex MiDAC has recently been shown to play
Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Baisakhi Mondal, Tanner Martinez, Satish Kallappagoudar, Andrey Tvardovskiy, Richa Bajpai, Beisi Xu, Shondra M Pruett-Miller, Robert Schneider, Hans-Martin Herz   +11 more
doaj   +1 more source

Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. [PDF]

PLoS ONE, 2013
Neurotrophins and modifiers of chromatin acetylation and deacetylation participate in regulation of transcription during neuronal maturation and maintenance.
Samira Chandwani, Serene Keilani, Maitane Ortiz-Virumbrales, Andrika Morant, Steve Bezdecny, Michelle E Ehrlich   +5 more
doaj   +1 more source

Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications [PDF]

Molecular and Cellular Biology, 2005
The class II deacetylase histone deacetylase 4 (HDAC4) negatively regulates the transcription factor MEF2. HDAC4 is believed to repress MEF2 transcriptional activity by binding to MEF2 and catalyzing local histone deacetylation. Here we report that HDAC4 also controls MEF2 by a novel SUMO E3 ligase activity.
Xuan, Zhao, Thomas, Sternsdorf, Timothy A, Bolger, Ronald M, Evans, Tso-Pang, Yao   +4 more
openaire   +2 more sources

Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4 [PDF]

Molecular and Cellular Biology, 2008
Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates histone deacetylase 4 (HDAC4), a class IIa HDAC, resulting in the cytosolic accumulation of HDAC4 and the derepression of the transcription factor myocyte enhancer factor 2. Phosphorylation by CaMKII requires docking of the kinase to a specific domain of HDAC4 not present in other ...
Johannes, Backs, Thea, Backs, Svetlana, Bezprozvannaya, Timothy A, McKinsey, Eric N, Olson   +4 more
openaire   +2 more sources

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. [PDF]

Cell, 2004
Histone deacetylases (HDACs) modulate cell growth and differentiation by governing chromatin structure and repressing the activity of specific transcription factors. We showed previously that HDAC9 acts as a negative regulator of cardiomyocyte hypertrophy and skeletal muscle differentiation.
Rick B. Vega, Koichi Matsuda, Junyoung Oh, Ana C. Barbosa, Xiangli Yang, Eric Meadows, J. McAnally, Chris Pomajzl, J. Shelton, J. Richardson, G. Karsenty, E. Olson   +11 more
semanticscholar   +3 more sources

Inhibition of alcohol-induced inflammation and oxidative stress by astaxanthin is mediated by its opposite actions in the regulation of sirtuin 1 and histone deacetylase 4 in macrophages.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2020
We previously demonstrated that astaxanthin (ASTX), a xanthophyll carotenoid, repressed ethanol-induced inflammation and oxidative stress in macrophages. We explored the role of sirtuin 1 (SIRT1) and histone deacetylase 4 (HDAC4) in the inhibitory effect
Hyunju Kang, Young-Ki Park, Ji-Young Lee
semanticscholar   +1 more source

Comparative genomics of the class 4 histone deacetylase family indicates a complex evolutionary history

BMC Biology, 2006
Background Histone deacetylases are enzymes that modify core histones and play key roles in transcriptional regulation, chromatin assembly, DNA repair, and recombination in eukaryotes. Three types of related histone deacetylases (classes 1, 2, and 4) are
Vervoort Michel, Ledent Valérie
doaj   +1 more source

HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors

Frontiers in Physiology, 2018
Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini, Nicoletta Marroncelli, Chiara Noviello, Viviana Moresi, Viviana Moresi, Sergio Adamo   +5 more
doaj   +1 more source