Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4. [PDF]
Diabetes Metab Syndr Obes, 2019 Purpose The aim of this study was to determine whether resveratrol (Rev) affects the expression, phosphorylation, and nuclear and cytoplasmic distribution of histone deacetylase 4 (HDAC4), which in turn affects gluconeogenesis in hepatocytes under an ...
Zhao H, Shu L, Huang W, Song G, Ma H.
europepmc +5 more sources
Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4. [PDF]
Nucleic Acids Res, 2018 Modification of chromatin and related transcription factors by histone deacetylases (HDACs) is one of the major strategies for controlling gene expression in eukaryotes.
Park SY +8 more
europepmc +5 more sources
Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke
Neurobiology of Disease, 2016 Mounting evidence suggests that epigenetic modifications play critical roles in the survival/death of stressed neurons. Chief among these modifications is the deacetylation of histones within the chromatin by histone deacetylases (HDACs). HDAC4 is highly
Hui Yuan +6 more
doaj +4 more sources
Stroke Induces Nuclear Shuttling of Histone Deacetylase 4. [PDF]
Stroke, 2015 Background and Purpose— Histone deacetylases (HDACs) 4 and 5 are abundantly expressed in the brain and have been implicated in the regulation of neurodegeneration.
Kassis H +4 more
europepmc +5 more sources
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1. [PDF]
Hepatology, 2015 Prohibitin‐1 (PHB1) is an evolutionarily conserved pleiotropic protein that participates in diverse processes depending on its subcellular localization and interactome.
Barbier-Torres L +17 more
europepmc +8 more sources
Definitions, 2020 Histone deacetylase 4 (1084 aa, ~119 kDa) is encoded by the human HDAC4 gene. This protein plays a role in the regulation of cell differentiation and histone deacetylation.
semanticscholar +2 more sources
Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4 [PDF]
Pharmaceuticals, 2021 Recently, we have reported that non-hydroxamate thiazolidinedione (TZD) analogs are capable of inhibiting human deacetylase 4 (HDAC4). This study aims at the dissection of the molecular determinants and kinetics of the molecular recognition of TZD ...
Markus Schweipert +9 more
doaj +2 more sources
Promotion of microRNA-146a by histone deacetylase 4 silencing contributes to radiosensitization of esophageal carcinoma [PDF]
Journal of Translational Medicine, 2022 Background Histone deacetylases (HDACs) have been identified to be implicated in the carcinogenesis and cancer progression. The present study was performed to probe into the effect of HDAC4 on radioresistance of esophageal carcinoma (EC).
Zhonghua Lu +4 more
doaj +2 more sources
miR-149-5p Inhibits Vascular Smooth Muscle Cells Proliferation, Invasion, and Migration by Targeting Histone Deacetylase 4 (HDAC4). [PDF]
Med Sci Monit, 2019 Background Studies have demonstrated that microRNAs (miRNAs) have essential roles in biological functions of vascular smooth muscle cells (VSMCs). However, the function and related molecular mechanism of miR-149-5p in VSMCs remains unclear.
Zhang B, Dong Y, Liu M, Yang L, Zhao Z.
europepmc +2 more sources
Histone Deacetylase 4 Promotes Osteosarcoma Cell Proliferation and Invasion by Regulating Expression of Proliferating Cell Nuclear Antigen. [PDF]
Front Oncol, 2019 Background/Aims: Osteosarcoma (OS) is commonly characterized by lower survival rates and high incidences of local recurrence due to its highly aggressive nature and metastatic tendencies.
Cao K +8 more
europepmc +2 more sources