Results 21 to 30 of about 167,650 (273)

Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosis. [PDF]

EBioMedicine, 2019
Background Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the disease ...
Pigna E, Simonazzi E, Sanna K, Bernadzki KM, Proszynski T, Heil C, Palacios D, Adamo S, Moresi V.   +8 more
europepmc   +2 more sources

Histone Deacetylase 4 Downregulation Elicits Post-Traumatic Psychiatric Disorders through Impairment of Neurogenesis. [PDF]

J Neurotrauma, 2019
An enduring deficit in neurogenesis largely contributes to the development of severe post-traumatic psychiatric disorders such as anxiety, depression, and memory impairment following traumatic brain injury (TBI); however, the mechanism remains obscure ...
Saha P, Gupta R, Sen T, Sen N.
europepmc   +2 more sources

Design and synthesis of peptides as stabilizers of histone deacetylase 4 [PDF]

Journal of Peptide Science
Histone deacetylase 4 (HDAC4) contributes to gene repression by complex formation with HDAC3 and the corepressor silencing mediator for retinoid or thyroid hormone receptors (SMRT).
Annika Lill, M. Schweipert, Thomas Nehls, Eva Wurster, Frederik Lermyte, F. Meyer-Almes, Katja Schmitz   +6 more
semanticscholar   +3 more sources

Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance Histone deacetylases (HDACs) are regulators of host gene expression. HDAC4 is shown here to have an important role in type I interferon (IFN) signaling. Here, multiple cell lines lacking HDAC4 had impaired responses to IFN-α and were rescued
Lu Y, Stuart JH, Talbot-Cooper C, Agrawal-Singh S, Huntly B, Smid AI, Snowden JS, Dupont L, Smith GL.   +8 more
europepmc   +2 more sources

Phosphatidylinositol 3‐Kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPlatelet‐derived growth factor BB, a potent mitogen of pulmonary artery smooth muscle cells (PASMCs), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension.
Yanjiao Li, Li Li, Zhengjiang Qian, Boya Lin, Jidong Chen, Yixuan Luo, Junle Qu, J. Usha Raj, Deming Gou   +8 more
doaj   +2 more sources

MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression. [PDF]

Int J Mol Sci, 2016
Chondrocyte hypertrophy, regulated by Runt-related transcription factor 2 (RUNX2) and matrix metalloproteinase 13 (MMP13), is a crucial step in cartilage degeneration and osteoarthritis (OA) pathogenesis. We previously demonstrated that microRNA-381 (miR-
Chen W, Sheng P, Huang Z, Meng F, Kang Y, Huang G, Zhang Z, Liao W, Zhang Z.   +8 more
europepmc   +2 more sources

miR-29b attenuates histone deacetylase-4 mediated podocyte dysfunction and renal fibrosis in diabetic nephropathy. [PDF]

J Diabetes Metab Disord, 2020
Gondaliya P, P Dasare A, Jash K, Tekade RK, Srivastava A, Kalia K.   +5 more
europepmc   +2 more sources

Histone Deacetylase 3 and 4 Complex Stimulates the Transcriptional Activity of the Mineralocorticoid Receptor.

PLoS ONE, 2015
Histone deacetylases (HDACs) act as corepressors in gene transcription by altering the acetylation of histones, resulting in epigenetic gene silencing.
Hae-Ahm Lee, Min-Ji Song, Young-Mi Seok, Seol-Hee Kang, Sang-Yeob Kim, Inkyeom Kim   +5 more
doaj   +4 more sources

Salt-inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification. [PDF]

EMBO Rep, 2017
Abend A, Shkedi O, Fertouk M, Caspi LH, Kehat I.   +4 more
europepmc   +2 more sources

Histone deacetylase 4: A therapeutic target for cardiovascular diseases (Review). [PDF]

Int J Mol Med
Cardiovascular disease (CVD) is a major global health threat, as its incidence and mortality rates continue to rise, highlighting the urgent need for effective therapeutic strategies. Histone deacetylase 4 (HDAC4), a member of class IIa HDACs, has attracted increasing attention in recent years for its role in CVD.
Ma X, Wei R, Song A, Zhang X, Zou J, Hao S.   +5 more
europepmc   +3 more sources