Results 101 to 110 of about 14,188 (207)
Hippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like Behavior
, 2014 Fluoxetine treatment in adulthood evokes antidepressant and anxiolytic responses. Paradoxically, postnatal fluoxetine (PNFlx) induces persistent depression- and anxiety-like behaviors.
Ambalika Sarkar +13 more
core +1 more source
SIK3-HDAC4 signaling in Cortex glia is critical for seizure behavior.
, 2023 (A) Representative images of larval peripheral nerves showing HDAC localization in wrapping glia (eag Shaker; Nrv2>HDAC4) and cortex glia (eag Shaker; Cortex>HDAC4) of eag Shaker mutants.
Lorenzo Lones (14374536) +1 more
core +1 more source
Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
Pharmaceutical Biology, 2019 Context: In vitro and in vivo research has shown that curcumin can alleviate diabetes and the relevant complications. Objective: To investigate the effect of curcumin on gestational diabetes (GD).
Xuehong Lu +4 more
doaj +1 more source
BMC Musculoskeletal DisordersBackground The present study evaluated whether the lack of histone deacetylase 4 (HDAC4) increases endoplasmic reticulum stress-induced chondrocyte apoptosis by releasing activating transcription factor 4 (ATF4) in human osteoarthritis (OA) cartilage ...
Xiaodong Gu +4 more
doaj +1 more source
Roles of Histone Deacetylase 4 in the Inflammatory and Metabolic Processes [PDF]
Diabetes & Metabolism JournalHistone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins ...
Hyunju Kang +3 more
doaj +1 more source
PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy
JCI Insight, 2019 During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte hypertrophy.
Shigeki Nishimori +7 more
openaire +3 more sources
HDAC4 overexpression predicts aggressive phenotypes and poor outcomes in urothelial carcinoma
Cancer Treatment and Research CommunicationsBackground: Aberrant epigenetic regulation contributes to cancer progression. Transcriptome profiling of bladder urothelial carcinoma (UBUC) (GSE31684) revealed that HDAC4 upregulation is associated with metastasis.
Hau-Chern Jan +5 more
doaj +1 more source
PKA cuts down on HDAC4 signaling
Journal of Cell Biology, 2011 ![Figure][1] In the presence of PKA and CaMKII, full-length HDAC4 (yellow) is cytoplasmic, but an N-terminal fragment (red) remains in the nucleus. Backs et al. report that protein kinase A (PKA) may protect the heart from stress by inducing the proteolytic cleavage of a ...
openaire +2 more sources
Impacts of HDAC4-MAP1S Interaction on Autophagy and Diseases [PDF]
, 2019 Autophagy is a cellular process to sequester cytoplasmic components for delivery to lysosomes for subsequent degradation, and plays important roles in aging and aging-associated pathogenesis. MAP1S is a ubiquitously distributed autophagy activator, which
Yue, Fei
core +2 more sources
Fiyz̤, 2020 Background: Histone Dacetylases-4 (HDAC4) is phosphorylated by calcium-calmodulin-dependent kinase (CaMKII) that plays an important role in cardiac tissue hypertrophy.
Mojdeh Khajehlandi +4 more
doaj