Results 121 to 130 of about 14,188 (207)

HDAC4 Gene [PDF]

, 2020
openaire   +1 more source

Structure-Based Identification of Novel Histone Deacetylase 4 (HDAC4) Inhibitors

Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. However, engineering specificity is an important goal.
Pawat Pattarawat, Jerome Baudry, Michael R. Duff, Hwa-Chain Robert Wang, Jeremy C. Smith, Rupesh Agarwal   +5 more
core   +1 more source

Research advances in role of histone deacetylase 4/5 in anxiety disorders

Shanghai Jiaotong Daxue xuebao. Yixue ban
Histone deacetylase 4/5 (HDAC4/5) mediate epigenetic regulation in stress-related disorders. Class Ⅱa HDACs feature signal-dependent shuttling between the nucleus and cytoplasm. By assembling complexes with transcription factors or co-repressors, HDAC4/5
Huo Sirui, Zhu Yongchuan
doaj   +1 more source

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

, 2012
Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promotes ...
Jianmin Chen, Melanie S Schwartz, Herrup, Karl, Chen, Jianmin, Christopher L Ricupero, Hart, Ronald P., Jiali Li, Li, Jiali, Kusnecov, Alexander, Schwartz, Melanie S., Ricupero, Christopher L., Alexander Kusnecov, Karl Herrup, Ronald P Hart   +13 more
core   +1 more source

Magnolol Inhibits High Fructose-Induced Podocyte Inflammation via Downregulation of TKFC/Sp1/HDAC4/Notch1 Activation

Pharmaceuticals
Background/Objectives: High fructose has been implicated as an important trigger of kidney inflammation in patients and experimental models. Magnolol, isolated from Magnolia officinalis, has an anti-inflammatory effect, but its protective role in ...
Ziang Zhou, Yumeng Wang, Yu Xing, Shuman Pan, Wanru Wang, Jie Yang, Wenyuan Wu, Jie Zhou, Luyi Huang, Qiongdan Liang, Dongmei Zhang, Lingdong Kong   +11 more
doaj   +1 more source

HDAC4 wt Allele [PDF]

, 2020
openaire   +1 more source

Effects of TLCA on HDAC4 expression in cultured primary HSCs.

, 2015
TLCA increased HDAC4 expression (A) and nuclear translocation (B) in HSCs of WT mice (white bar). HSCs of miR-29a transgenic mice (gray bar) exhibited significantly reduced upregulation and nuclear translation of HDAC4 in response to TLCA stimulation ...
Mao-Meng Tiao (446593), Ying-Hsien Huang (446595), Jiin-Haur Chuang (171983), Li-Tung Huang (280487), Kuang-Che Kuo (787054), Feng-Sheng Wang (787055), Ya-Ling Yang (664304)   +6 more
core   +1 more source

Histone deacetylase 4 (HDAC4) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming.

, 2007
Neural activity actively regulates muscle gene expression. This regulation is crucial for specifying muscle functionality and synaptic protein expression. How neural activity is relayed into nuclei and connected to the muscle transcriptional machinery,
Cohen, T J, Feng, G, Yao, T P, Barrientos, T, Waddell, D S, Lu, Z, Cox, G A, Bodine, S C   +7 more
core  

Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma. [PDF]

Mol Med
Henning S, Kutzner TJ, Schneider M, González-Gimeno T, Zheng Y, Berchner-Pfannschmidt U, Helm D, Giebel B, Bechrakis NE, Peña-Llopis S.   +9 more
europepmc   +1 more source