Results 111 to 120 of about 14,188 (207)

Mesenchymal Stem Cell–Originated Exosomal Circular RNA circFBXW7 Attenuates Cell Proliferation, Migration and Inflammation of Fibroblast-Like Synoviocytes by Targeting miR-216a-3p/HDAC4 in Rheumatoid Arthritis

Journal of Inflammation Research, 2021
Lihua Chang,1 Liang Kan2 1Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China; 2Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical ...
Chang L, Kan L
doaj  

HDAC4 interacts with both the MR and HDAC3.

, 2015
A, HEK293 cells were transfected with MR-HA and either HDAC4-Flag, HDAC5-Flag, or HDAC7-Flag plasmids. After 48 h, the cells were treated with Aldo (10 nM) for 30 min. Whole-cell lysates (WCLs) were prepared with non-denaturing lysis buffer.
Sang-Yeob Kim (317878), Young-Mi Seok (787355), Seol-Hee Kang (787356), Hae-Ahm Lee (787353), Min-Ji Song (787354), Inkyeom Kim (787357)   +5 more
core   +1 more source

The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy

Journal of Inflammation Research, 2022
Zhengquan Dong,1 Zhou Ma,1 Meiju Yang,2 Linlin Cong,2 Ruipeng Zhao,1 Liyun Cheng,3 Jian Sun,1 Yunfei Wang,1 Ruijia Yang,2 Xiaochun Wei,1 Pengcui Li1 1Department of Orthopaedic, Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, The Second ...
Dong Z, Ma Z, Yang M, Cong L, Zhao R, Cheng L, Sun J, Wang Y, Yang R, Wei X, Li P   +10 more
doaj  

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Curcumin attenuates pressure overload-induced cardiac fibrosis in mice via modulating the miR-29b/HDAC4 axis

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the antifibrotic effects of curcumin in a transverse aortic constriction (TAC) mouse model and elucidate its molecular mechanisms. Methods: Male C57BL/6 mice underwent TAC and received vehicle, low-dose curcumin (50 mg/kg), high-
Yu Xiang, Ying Lv, Xiao-Xiang Liu, Bo-Tao Li, Jing Liu   +4 more
doaj   +1 more source

Effect of irisin on HDAC4 expression in transcriptional and protein levels.

, 2016
(A) Quantitative PCR results of HDAC4. It showed that irisin did not influence HDAC4 mRNA. (B) Western blot analysis of HDAC4. Irisin treatment resulted in a time-dependent decrease in HDAC4 level. The results represent 3–4 independent experiments.
Shouyan Zhang (3359156), Shougang Zhuang (102960), Ting C. Zhao (102950), Jianfeng Du (420016), Yu Tina Zhao (3359159), Hao Wang (39217)   +5 more
core   +1 more source

HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor [PDF]

, 1999
Histone acetylation plays an important role in regulating chromatin structure and thus gene expression. Here we describe the functional characterization of HDAC4, a human histone deacetylase whose C-terminal part displays significant sequence similarity ...
Bertos, N. R., Th'ng, J., Heng, H. H., 韩家淮, Han, J. H., Wang, A. H., Yang, X. J., Vezmar, M., Pelletier, N., Crosato, M.   +9 more
core  

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

, 2008
The class II Histone deacetylase (HDAC), HDAC4, is expressed in a tissue-specific manner, and it represses differentiation of specific cell types. We demonstrate here that HDAC4 is expressed in the proliferative zone in small intestine and colon and that
Wilson, Andrew J, Figueroa, Maria, Arango, Diego, John M. Mariadason, Augenlicht, Leonard H, Leonard H. Augenlicht, Mariadason, John M, Kanyalakshmi Ayyanar, Melnick, Ari, Ayyanar, Kanyalakshmi, Lucas B. Murray, Maria Figueroa, Gary D. Kao, Andrew J. Wilson, Shannon Nasser, Ari Melnick, Nasser, Shannon, Murray, Lucas B, Diego Arango, Do-Sun Byun, Byun, Do-Sun, Kao, Gary D   +21 more
core   +1 more source

Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4

, 2011
Histone deacetylase 4 (HDAC4) regulates numerous gene expression programs through its signal-dependent repression of myocyte enhancer factor 2 (MEF2) and serum response factor (SRF) transcription factors.
Lorenz H. Lehmann, David M. Patrick, Qiang Sun, Eric N. Olson, Lan Chen, Michael M. Kreusser, Johannes Backs, Zegeye Jebessa, Hugo A. Katus, Barbara C. Worst, Claudia Heft   +10 more
core   +1 more source

LINC00847 drives pancreatic cancer progression by targeting the miR-455-3p/HDAC4 axis

Archives of Medical Science
Introduction Pancreatic cancer (PC) is a common malignant tumor of the digestive system, posing a serious threat to the life of patients. This study aims to investigate the role of LINC00847 and the LINC00847/miR-455-3p/HDAC4 mechanism in PC progression.
Shunxin Hao, Zhi Yao, Yifeng Liu
doaj   +1 more source