Results 141 to 150 of about 137,192 (357)

Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells [PDF]

, 2005
Yoko Tabe, Marina Konopleva, Rooha Contractor, Mark F. Munsell, Wendy Schober, Linhua Jin, Yuko Tsutsumi‐Ishii, Isao Nagaoka, J Igari, Michael Andreeff   +9 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross‐resistance to a wide range of DNA‐damaging drugs [PDF]

, 2008
Kei‐ichi Ozaki, Futaba Kishikawa, Masashi Tanaka, Toshiaki Sakamoto, Susumu Tanimura, Michiaki Kohno   +5 more
openalex   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, EarlyView.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models

, 2020
Satish Noonepalle, Sida Shen, J. Ptáček, Maurício T. Tavares, Guiping Zhang, Jan Stránský, Jiřı́ Pavlı́ček, Gláucio Monteiro Ferreira, Melissa Hadley, Guido D. Pelaez, Cyril Bařinka, Alan P. Kozikowski, Alejandro Villagra   +12 more
openalex   +1 more source

The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPARγ and Adipocyte Differentiation [PDF]

, 2002
Lluís Fajas, Viviane Egler, Raphael Reiter, Jacob B. Hansen, Karsten Kristiansen, Marie-Bernard Debril, Stéphanie Miard, Johan Auwerx   +7 more
openalex   +1 more source

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. [PDF]

, 2002
The yeast silent information regulator (Sir)2 protein links cellular metabolism and transcriptional silencing through its nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase activity.
Frye, Roy A, North, Brian J, Ott, Melanie, Schwer, Bjorn, Verdin, Eric   +4 more
core  

Compensation Response to Hepatic Gluconeogenesis via β‐Hydroxybutyrylation of FBP1 and PCK1 in Dairy Cows

Animal Research and One Health, EarlyView.
(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng, GuoYan Wang, YuanYuan Zhu, YiNing Zheng, JunHu Yao, Lei Chen, Lu Deng   +6 more
wiley   +1 more source

Multi‐Omics Insights Into the Role of Fructooligosaccharides Supplementation in Alleviating Salpingitis in Laying Hens

Animal Research and One Health, EarlyView.
Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song, Tao Duan, Rong Li, Xiaoqiu Wang, Fengdong Zhang, Jia Feng, Lin Qiao, Junlin Cheng, Lixian Chen, Aike Li, Yuna Min, Weiwei Wang   +11 more
wiley   +1 more source