Results 161 to 170 of about 152,498 (307)

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor.

Blood, 2013
A. Chakraborty, R. Robey, Victoria L. Luchenko, Zhi-Rong Zhan, R. Piekarz, J. Gillet, A. Kossenkov, J. Wilkerson, L. Showe, M. Gottesman, N. Collie, S. Bates   +11 more
semanticscholar   +1 more source

Infection mechanisms of Rhizoctonia cerealis in wheat

iMeta, EarlyView.
We discover that R. cerealis (Rc) is a primary pathogen causing sharp eyespot of wheat after 335 distinct isolates were isolated from 1683 SE‐diseased wheat plants across China over 7 years using a single hyphal tip isolation method. We then generated high‐quality reference genomes via de novo sequencing of five representative Rc isolates and ...
Yan Ren, Ti Liu, Heying Zhao, Qirun Qian, Lufei Cui, Zhipeng Sun, Wenkai Yang, Peng Guo, Sisheng Wang, Lingran Zhang, Congwei Sun, Aolin Jia, Ning Zhang, Feng Chen   +13 more
wiley   +1 more source

Off-target binding of the histone deacetylase inhibitor vorinostat to carbonic anhydrase II and IX. [PDF]

Acta Crystallogr F Struct Biol Commun
Gulkis MC, Hodgkinson JT, Sele CP, Knecht W, McKenna R, Fisher SZ.   +5 more
europepmc   +1 more source

Synthesis and Biological Evaluation of the First Example of NO-Donor Histone Deacetylase Inhibitor.

ACS Medicinal Chemistry Letters, 2013
Emily Borretto, L. Lazzarato, Francesco Spallotta, C. Cencioni, Y. D'Alessandra, C. Gaetano, R. Fruttero, A. Gasco   +7 more
semanticscholar   +1 more source

Decoding ferroptosis via integrated multi‐omics analyses in rice blast

iMeta, EarlyView.
The rice‐Magnaporthe oryzae pathosystem is presented as a host‐pathogen ferroptosis model. Multi‐omics insights connect ferroptosis to several cellular processes, such as iron homeostasis, reactive oxygen species (ROS)/redox imbalance, and polyunsaturated fatty acid‐containing phospholipid (PUFA‐PL) peroxidation, under multiple regulators in rice and M.
Zhibin Liang, Qing Shen, Nam Khoa Nguyen, Ruhui Long, Yuming Ma, Qiao Liu, Naweed I. Naqvi, Nam‐Soo Jwa, Yi‐Zhen Deng   +8 more
wiley   +1 more source

Histone Deacetylase Inhibitor Combined with Rosiglitazone Improves Cognitive Function Via Microglial Polarization and Increased Mature/Pro-BDNF in Alzheimer's Disease. [PDF]

Adv Pharm Bull
Rafiey M, Nosrati R, Pourgholaminejad A, Ahangaran S, Babaei P.   +4 more
europepmc   +1 more source

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma.

Journal of Clinical Oncology, 2009
R. Piekarz, Robin Frye, M. Turner, J. Wright, S. Allen, M. Kirschbaum, J. Zain, H. Prince, J. P. Leonard, L. Geskin, C. Reeder, D. Joske, W. Figg, E. Gardner, Seth M. Steinberg, E. Jaffe, M. Stetler-Stevenson, S. Lade, A. Fojo, S. Bates   +19 more
semanticscholar   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

The histone deacetylase inhibitor Scriptaid targets G-quadruplexes. [PDF]

Open Biol
Sanchez-Martin V, Ruzic D, Tello-Lopez MJ, Ortiz-Morales A, Murciano-Calles J, Soriano M, Nikolic K, Garcia-Salcedo JA.   +7 more
europepmc   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source