Results 171 to 180 of about 76,892 (257)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Molecular heterogeneity of BCL2/MYC double expressor lymphoma underlies sensitivity to histone deacetylase inhibitor. [PDF]

Clin Transl Med
Shi ZY, Fang Y, Xu PP, Yi HM, Li JF, Dong Y, Zhu Y, Liu MK, Fu D, Wang S, Shi Q, Shen R, Zhong HJ, Wang CF, Cheng S, Wang L, Liu F, Zhao WL.   +17 more
europepmc   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells. [PDF]

Front Cell Neurosci
Inoue Y, Ren Y, Zhang S, Bamkole M, Islam NN, Selvaraj M, Lu W, Caulfield TR, Li Y, Kanekiyo T.   +9 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

A Voxel‐Wise T2 Distribution Framework for Lesion Severity Stratification and Treatment‐Response Assessment in Stroke: Insights Into Suberoylanilide Hydroxamic Acid‐Induced Neuroprotection

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate lesion severity distribution in ischaemic brain lesions in spontaneously hypertensive rats (SHR) subjected to 90‐min transient middle cerebral artery occlusion (tMCAO), and to determine whether epigenetically based neuroprotection modifies lesion severity profiles using a voxel‐wise T2 distribution framework.
Andrea Díaz‐Pérez, Clara Penas, Francesc Jiménez‐Altayó, Silvia Lope‐Piedrafita   +3 more
wiley   +1 more source

Histone deacetylase inhibitor decreases hyperalgesia in a mouse model of alcohol withdrawal-induced hyperalgesia. [PDF]

Alcohol Clin Exp Res (Hoboken)
Aguilar J, De Carvalho LM, Chen H, Condon R, Lasek AW, Pradhan AA.   +5 more
europepmc   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Correction to "The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukaemia cells". [PDF]

J Cell Mol Med
europepmc   +1 more source

A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy. [PDF]

ACS Pharmacol Transl Sci
Wu B, Tapadar S, Ruan Z, Sun CQ, Arnold RS, Johnston A, Olugbami JO, Arunsi U, Gaul DA, Petros JA, Kobayashi T, Duda DG, Oyelere AK.   +12 more
europepmc   +1 more source