Results 191 to 200 of about 152,498 (307)

Development of a histone deacetylase 6 inhibitor and its biological effects

Proceedings of the National Academy of Sciences of the United States of America, 2013
Ju-Hee Lee, Adaickapillai Mahendran, Yuanshan Yao, L. Ngo, G. Venta-Perez, M. L. Choy, Nathaniel Kim, W. Ham, R. Breslow, P. Marks   +9 more
semanticscholar   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

Identification of a histone deacetylase inhibitor as a therapeutic candidate for congenital central hypoventilation syndrome. [PDF]

Mol Ther Nucleic Acids
Africano C, Bachetti T, Uva P, Pitollat G, Del Zotto G, Giacopelli F, Recchi G, Lenfant N, Madani A, Beckouche N, Thoby-Brisson M, Ceccherini I.   +11 more
europepmc   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

The Impact of the Histone Deacetylase Inhibitor-Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia-Ischemia. [PDF]

Mol Neurobiol
Ziabska K, Gewartowska M, Frontczak-Baniewicz M, Sypecka J, Ziemka-Nalecz M.   +4 more
europepmc   +1 more source

Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees

EMBO Reports, 2011
Astrid Spannhoff, Yong Kee Kim, Noel J.-M. Raynal, Vazganush Gharibyan, Ming-Bo Su, Yue Zhou, Jia Li, S. Castellano, Gianluca Sbardella, Jean-Pierre J. Issa, Mark T. Bedford   +10 more
semanticscholar   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Preconditioning of Human Umbilical Cord Mesenchymal Stem Cells with a Histone Deacetylase Inhibitor: Valproic Acid. [PDF]

Balkan Med J
Işıldar B, Özkan S, Koyutürk M.
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat. [PDF]

Neoplasia
Zenz T, Jenke R, Oliinyk D, Noske S, Thieme R, Kahl T, Gockel I, Meier-Rosar F, Aigner A, Büch TR.   +9 more
europepmc   +1 more source