Results 181 to 190 of about 152,498 (307)

Exploring the potential of Gonolobus condurango as a histone deacetylase inhibitor in triple-negative breast cancer cell lines: in vitro study. [PDF]

BMC Complement Med Ther
Vajen B, Schäffer V, Eilers M, Schlegelberger B, Skawran B.   +4 more
europepmc   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Brain-penetrant histone deacetylase inhibitor RG2833 improves spatial memory in females of an Alzheimer's disease rat model. [PDF]

J Alzheimers Dis
Ndukwe K, Serrano PA, Rockwell P, Xie L, Figueiredo-Pereira ME.   +4 more
europepmc   +1 more source

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

Proceedings of the National Academy of Sciences of the United States of America, 2012
Noor Gammoh, Du Lam, Cindy Puente, I. Ganley, P. Marks, Xue-Jun Jiang   +5 more
semanticscholar   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies. [PDF]

J Med Chem
Chen IC, Lin HY, Liu ZY, Cheng WJ, Yeh TY, Yang WB, Tran HY, Lai MJ, Wang CH, Kao TY, Hung CY, Huang YL, Liou KC, Hsieh CM, Hsu TI, Liou JP.   +15 more
europepmc   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression. [PDF]

Front Immunol
Jo DH, Kaczmarek S, Khan AUH, Pervin J, Clark DM, Gadde S, Wang L, McComb S, Visram A, Lee SH.   +9 more
europepmc   +1 more source

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Proceedings of the National Academy of Sciences of the United States of America, 2003
S. Haggarty, Kathryn M. Koeller, J. Wong, C. Grozinger, S. Schreiber   +4 more
semanticscholar   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source