Results 151 to 160 of about 152,498 (307)

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Novel histone deacetylase inhibitor, CS014, attenuates in vivo thrombosis while maintaining hemostasis. [PDF]

J Thromb Haemost
Stanger L, Yalavarthi P, Adili R, Gilmore D, Hoang T, Campbell A, Krenik P, Gustafsson D, Fryklund J, Fex T, Oakes N, Säljö JF, Dahlöf B, Beckman J, Holinstat M.   +14 more
europepmc   +1 more source

Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus. [PDF]

Arthritis Rheumatol
Hirayama T, Konaka H, Kato Y, Shibahara T, Nishizawa C, Tsujimoto K, Park J, Itotagawa E, Jo T, Nishide M, Nishida S, Shima Y, Narazaki M, Aoki W, Ishii KJ, Takamatsu H, Kumanogoh A.   +16 more
europepmc   +1 more source

The histone deacetylase inhibitor CG-745 enhances the radiosensitivity of prostate cancer cells. [PDF]

J Int Med Res
Wu B, Liao SG.
europepmc   +1 more source

NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor. [PDF]

Cancers (Basel), 2023
Ashry R, Mustafa AM, Hausmann K, Linnebacher M, Strand S, Sippl W, Wirth M, Krämer OH.   +7 more
europepmc   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

Hyperagonism of a Vitamin D Receptor Agonist/Histone Deacetylase Inhibitor Hybrid Molecule. [PDF]

J Med Chem
Sarmadi F, Caza A, Gao Z, Rochel N, Gleason JL, White JH.   +5 more
europepmc   +1 more source

Inhibition of Notch Signaling Enhances Antitumor Activity of Histone Deacetylase Inhibitor LAQ824. [PDF]

Int J Mol Sci, 2023
Mei Q, Xu X, Gao D, Xu Y, Yang J.
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Chidamide (a Histone Deacetylase Inhibitor) Plus Abiraterone in Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Phase Ib Trial. [PDF]

MedComm (2020)
Rong QX, Chen MT, Yang W, Huang RQ, Shu DT, Zhang Y, Xue C, Cai YC, An X, Li HF, Shi YX.   +10 more
europepmc   +1 more source