Results 141 to 150 of about 152,498 (307)

Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer.

Journal of Clinical Oncology, 2005
W. Kelly, O. O'Connor, L. Krug, J. Chiao, M. Heaney, T. Curley, Barbara MacGregore-Cortelli, W. Tong, J. Secrist, L. Schwartz, S. Richardson, E. Chu, Semra Olgac, Paul A. Marks, H. Scher, V. Richon   +15 more
semanticscholar   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, EarlyView.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Differential transcriptomic modulation by histone deacetylase inhibitor SAHA in LUAD and LUSC. [PDF]

Clin Epigenetics
Wang F, Yang Q, Shu L, Cen H, Huang Y, Ma X, Lin Y, Guan X, Wang C, Fu X, You G, Yu XY, Zhang L, Su J.   +13 more
europepmc   +1 more source

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

Proceedings of the National Academy of Sciences of the United States of America, 2003
E. Hockly, V. Richon, B. Woodman, Donna L. Smith, Xianbo Zhou, E. Rosa, Kirupa Sathasivam, S. Ghazi-Noori, A. Mahal, PhilipA.S Lowden, J. S. Steffan, J. Marsh, L. Thompson, C. Lewis, P. Marks, G. Bates   +15 more
semanticscholar   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Anti-tumor effect of a histone deacetylase inhibitor on canine malignant melanoma. [PDF]

J Vet Med Sci
Li T, Shibahara H, Kato D, Kodera Y, Ikeda N, Shinada M, Iguchi T, Shiyu Q, Ando M, Koseki S, Kako T, Motoi H, Hashimoto Y, Takahashi Y, Nishimura R, Nakagawa T.   +15 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

NF-κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor-Resistant Cutaneous T-Cell Lymphoma. [PDF]

Cancer Sci
Takahashi Y, Kitadate A, Iwama S, Kuroki W, Abe K, Yamada M, Ikeda S, Tagawa H, Wakui H, Hikida M, Takahashi N.   +10 more
europepmc   +1 more source

Toxicity prediction and analysis of flavonoid apigenin as a histone deacetylase inhibitor: an in-silico approach. [PDF]

In Silico Pharmacol, 2023
Divya Rajaselvi N, Jida MD, Nair DB, Sujith S, Beegum N, Nisha AR.   +5 more
europepmc   +1 more source

Histone deacetylase inhibitor enhances recovery after AKI.

Journal of the American Society of Nephrology, 2013
Chiara Cianciolo Cosentino, Nataliya I. Skrypnyk, Lauren L. Brilli, Takuto Chiba, Tatiana Novitskaya, Clara Woods, James D. West, V. Korotchenko, L. Mcdermott, B. Day, A. Davidson, Raymond C. Harris, M. de Caestecker, N. Hukriede   +13 more
semanticscholar   +1 more source