Results 261 to 270 of about 113,596 (299)
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Prospects: Histone deacetylase inhibitors
Journal of Cellular Biochemistry, 2005AbstractHistone deacetylase (HDAC), inhibitors represent a new class of targeted anti‐cancer agents. Several of these compounds are in clinical trials with significant activity against a spectrum of both hematologic and solid tumors at doses that are well tolerated by the patients.
Milos, Dokmanovic, Paul A, Marks
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Histone deacetylase inhibitors in lymphoma
Current Opinion in Oncology, 2010Although many advances have been made in the treatment of lymphoma in the past decade, the treatment of patients with relapsed and refractory disease remains challenging. Only a fraction of patients will be cured with salvage therapy and transplantation.
Amanda, Copeland +2 more
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Histone Deacetylase Inhibitors In Inflammatory Disease
Current Topics in Medicinal Chemistry, 2009Lysine acetylation is becoming increasingly appreciated as a key post-translational modification in the endogenous regulation of protein function. The so-called histone acetyl transferases (HATs) and histone deacetylases (HDACs), best known for their roles in controlling chromatin remodeling via histone acetylation/deacetylation, are now known to ...
Halili, M. A. +3 more
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Function of Histone Deacetylase Inhibitors in Inflammation
Critical Reviews™ in Immunology, 2011Histone deacetylases (HDACs) display multi-faceted roles in coordinating the interaction of intracellular signaling pathways with chromatin remodeling and transcription factor function to finely specify gene alterations and maintenance of gene expression during cellular activation, proliferation, and differentiation. These processes, epigenetic and non-
Grabiec, Aleksander M. +2 more
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Histone Deacetylase Inhibitors
2021Histone Deacetylase Inhibitors (HDACi) inhibits deacetylases of histones and nonhistones. As such it has potential widespread biological effects. However, cancer cells are preferentially affected than normal cells making it a useful targeted therapy in cancer.
Opelo Sefhore, Silvia CW Ling
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Anticancer activities of histone deacetylase inhibitors
Nature Reviews Drug Discovery, 2006Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic regulation of gene expression. In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypo-acetylation.
Ricky W Johnstone
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Hydrazides as Inhibitors of Histone Deacetylases
Journal of Medicinal ChemistryIn this Perspective, we have brought together available biological evidence on hydrazides as histone deacetylase inhibitors (HDACis) and as a distinct type of Zn-binding group (ZBG) to be reviewed for the first time in the literature. N-Alkyl hydrazides have transformed the field, providing innovative and practical chemical tools for selective and ...
Maria do Carmo Carreiras +1 more
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Histone deacetylase inhibitors
Expert Opinion on Therapeutic Patents, 2007Sustained efforts towards identifying novel histone deacetylase (HDAC) inhibitors as suitable therapies for the treatment of cancer and other human diseases has been a goal for the pharmaceutical industry during the last decade. In the second half of 2006 these efforts culminated in the FDA granting approval for the first HDAC inhibitor ...
Steve Price, Hazel J Dyke
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The Pharmaceutical Potential of Histone Deacetylase Inhibitors
Current Pharmaceutical Design, 2007Protein acetylation, catalyzed by the opposing activities of histone deacetylases (HDAC) and histone acetyltransferases, is now recognized to be an important epigenetic modulator of gene transcriptional activity and cell function. As a result of the intense search for HDAC inhibitors (HDACi) during the past fifteen years, a large number of structurally
Elaut, Greetje +2 more
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Heterocyclic ketones as inhibitors of histone deacetylase
Bioorganic & Medicinal Chemistry Letters, 2003Several heterocyclic ketones were investigated as potential inhibitors of histone deacetylase. Nanomolar inhibitors such as 22 and 25 were obtained, the anti-proliferative activity of which were shown to be mediated by HDAC inhibition.
Anil, Vasudevan +15 more
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