Histone deacetylase inhibitors - Open Access .click

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Selective Histone Deacetylase Inhibitors

Anti-Cancer Agents in Medicinal Chemistry, 2012
Histone deacetylases (HDACs) are a family of conserved metalloproteases which play a key role in the development of cancer. They can be divided into 18 subtypes according to their structural diversity. Histone deacetylase inhibitors are considered as potential anti-cancer agents and a lot of pan-HDAC inhibitors have entered clinical trials.
Huili, Pan, Jiangying, Cao, Wenfang, Xu
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Hydrazides as Inhibitors of Histone Deacetylases

Journal of Medicinal Chemistry
In this Perspective, we have brought together available biological evidence on hydrazides as histone deacetylase inhibitors (HDACis) and as a distinct type of Zn-binding group (ZBG) to be reviewed for the first time in the literature. N-Alkyl hydrazides have transformed the field, providing innovative and practical chemical tools for selective and ...
Maria do Carmo Carreiras, José Marco-Contelles +1 more
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Inhibitors of Histone-deacetylases

Tumori Journal, 2001
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INHIBITORS OF HISTONE DEACETYLASE