Results 121 to 130 of about 53,170 (215)

Epigenetic Dysregulation in Neurodegeneration: The Role of Histone Deacetylases and Emerging Inhibitor Strategies. [PDF]

Biomolecules
Pawar Y, Kopranovic A, C S R, Meyer-Almes FJ.   +3 more
europepmc   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

FSP1 and histone deacetylases suppress cancer persister cell ferroptosis. [PDF]

Sci Adv
Higuchi M, Williams AF, Stuhlfire AE, Nguyen AH, Gervasio DAG, Turkal CE, Chon S, Hangauer MJ.   +7 more
europepmc   +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Stage-Specific Expression of Histone Deacetylases in the Mouse Mandibular Condylar Cartilage. [PDF]

Cartilage
Yang C, Li H, Kong J, Wang M, Wang J, Guo X, Zhan Y.   +6 more
europepmc   +1 more source

Organ‐Resolved Host Proteomic and Post‐Translational Modification Landscapes in a Mouse Model of Talaromyces marneffei Infection

iMetaMed, EarlyView.
We presented an organ‐resolved, multiple PTM remodeling atlas of systemic T. marneffei infection, integrating quantitative proteome, phosphoproteome, ubiquitinome, acetylome, and lactylome data across the liver, lung, and spleen. The atlas delineated organ‐specific PTM signatures and a functional convergence of divergent modification types on immune ...
Wudi Wei, Shiyi Lai, Xiaotao He, Xiaoting Wei, Xiaoting Xie, Weihong Huang, Baili Zhan, Meng Zhang, Zongxiang Yuan, Rongfeng Chen, Jingzhen Lai, Yuyuan Huang, Kang Li, Sanqi An, Li Ye, Hao Liang, Junjun Jiang   +16 more
wiley   +1 more source

Histone deacetylases and cell-cycle regulators orchestrate cell-identity transitions during Arabidopsis root regeneration. [PDF]

Mol Plant
Rahni R, Lee LR, Vissers G, Suresh I, Gorodokin BM, Ip PL, Guillotin B, Birnbaum KD.   +7 more
europepmc   +1 more source

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

iMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao, Hang You, Zongyi Liu, Yong Sun, Yu Zhang, Li Wei, Ning Ling, Hong Ren, Shiying Li, Peng Hu, Mingli Peng   +10 more
wiley   +1 more source

Novel Azaborine-Based Inhibitors of Histone Deacetylases (HDACs). [PDF]

Molecules
Behringer M, Schweipert M, Peters EE, Kopranovic A, Meyer-Almes FJ.   +4 more
europepmc   +1 more source

OXCT1‐driven succinylation of PSMG3 stabilizes the proteasome to facilitate picornavirus replication

iMetaOmics, EarlyView.
Upon entering the pig, foot‐and‐mouth disease virus (FMDV) regulates host glycolysis and the citrate cycle by modulating the expression of metabolic enzymes, resulting in changes in post‐translational modifications (PTMs) including succinylation, lactylation, crotonylation, acetylation, and phosphorylation.
Huisheng Liu, Qiao Xue, Pengfei Liu, Zhihua Dong, Weijun Cao, Fan Yang, Yingming Zhu, Lei Deng, Zixiang Zhu, Haixue Zheng   +9 more
wiley   +1 more source