Results 111 to 120 of about 53,170 (215)

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication. [PDF]

Elife
Ming SL, Du MH, Yang JM, Guo YD, Pan JJ, Lu WF, Wang J, Zeng L, Chu BB.   +8 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Integrating stress responses and secondary metabolism: the regulatory functions of histone deacetylases in medicinal plants. [PDF]

Front Plant Sci
Yang Y, Tang D, Zhang R, Liu M, Feng T.
europepmc   +1 more source

KBG syndrome: A scoping review of electroclinical features of patients with epilepsy

Epileptic Disorders, EarlyView.
Abstract Background and Objectives KBG syndrome is a rare autosomal developmental disorder caused by pathogenic variants of the ANKRD11 gene. This scoping review aimed to explore all current literature data regarding clinical and electroencephalographic features of patients with KBG syndrome and epilepsy. Materials and Methods We conducted a literature
Stefania Kalampokini, Evripidis Pityrigkas, Zoi Kallia, Georgia Pepe, Antonis Frontistis, Dimitrios Profer, Vasilios Kimiskidis   +6 more
wiley   +1 more source

Histone deacetylases: Function in tumor development and therapeutic prospects (Review). [PDF]

Oncol Lett
Lin R, Zhang Y, Li H, Liang F.
europepmc   +1 more source

Clinicoepidemiologic Profile of Oral Kaposi Sarcoma in People Living With HIV: A Systematic Review and Meta‐Analysis

Head &Neck, EarlyView.
ABSTRACT Background To characterize the clinicoepidemiologic profile of HIV‐associated oral Kaposi sarcoma (OKS) and quantitatively synthesize its frequency, anatomical distribution, and temporal patterns across antiretroviral therapy (ART) eras. Methods Six databases and gray literature were searched.
Ericles Otávio, Rebeca Ferreira Badaró, Daniel Pignatari Mahet Rodrigues, Giselle de Medeiros Silva, José Alcides Almeida de Arruda, Victor Zanetti Drumond, Jefferson R. Tenório, Lucas Alves Jural, Marcela Baraúna Magno, Lucianne Cople Maia, Bruno Augusto Benevenuto de Andrade   +10 more
wiley   +1 more source

Functional divergence and structural changes of Class IV histone deacetylases (HDACs) across the tree of life. [PDF]

Mol Biol Evol
Nováková Z, Bartošová-Sojková P, Kudláčová J, Baselious F, Kutilová Z, Jaklová P, Meleshin M, Motlová L, Schenkmayerova A, Vrkoslav V, Strnad Š, Horáček N, Gruber A, Žáček P, Kroll S, Havlínová B, Ondráková M, Tučková R, Krunclová T, Cvačka J, Oborník M, Schutkowski M, Sippl W, Bařinka C.   +23 more
europepmc   +1 more source

Discovery of a CI-994 derivative as a dual modulator of class I histone deacetylases and Wnt/β-catenin signaling for Alzheimer's disease therapy. [PDF]

Neurotherapeutics
Lu W, Caulfield TR, Lee E, Jeevaratnam S, Wang N, Bu G, Kanekiyo T, Li Y.   +7 more
europepmc   +1 more source