Results 221 to 230 of about 98,157 (333)

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection, EarlyView.
Three‐panel graphical abstract showing the Lifelong Neurobiological Trajectory framework for Parkinson's disease: (1) Vulnerability pathway (top, red) showing how early adversity → epigenetic dysregulation, neuroinflammation, and mitochondrial dysfunction → ↑ PD risk; (2) Lifespan timeline (middle, purple) spanning prenatal/infancy → childhood ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
wiley   +1 more source

Inhibition of Histone Deacetylases Induces Cancer Cell Apoptosis Through the PERK Pathway of ER Stress Response. [PDF]

J Cell Mol Med
Wang X, Yang C, Yang Y, Xu F, Yuan D, Gu Y.   +5 more
europepmc   +1 more source

The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis. [PDF]

Int J Mol Sci, 2023
Xu L, Yan X, Wang J, Zhao Y, Liu Q, Fu J, Shi X, Su J.   +7 more
europepmc   +1 more source

EXTH-11. HISTONE DEACETYLASE 6 (HDAC6) INHIBITORS RETARD CELL PROLIFERATION AND INDUCE ROBUST CELL DEATH IN GLIOBLASTOMA (GBM) CELLS AND GBM SPHEROIDS CONTAINING STEM CELLS [PDF]

, 2016
M. Reza Saadatzadeh
openalex   +1 more source

Histone deacetylase 6 (HDAC6); histone deacetylase 8 (HDAC8) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source

Epigenetic Histone Deacetylases Activity Assay in the Brain and Peripheral Organ Tissues. [PDF]

Curr Protoc
Reddy DS, Boyd H, Karnati V, Kim J, Ramakrishnan S, Wu X.   +5 more
europepmc   +1 more source

Development of Fluorogenic Probes for the Detection of Histone Deacetylase Activity

, 2015
Yuichiro Hori, Reisuke Baba, Kazuya Kikuchi   +2 more
openalex   +2 more sources

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer. [PDF]

World J Gastroenterol
Nie HH, Yang XY, Zhou JK, Gao GL, Ding L, Hong YT, Yu YL, Qiu PS, Zeng ZY, Lai J, Zheng T, Wang HZ, Zhao Q, Wang F.   +13 more
europepmc   +1 more source