Results 211 to 220 of about 51,098 (257)
Deacetylase inhibitors CM‐444 and CM‐1758 enhance chemotherapy response in AML via ALOX5
British Journal of Haematology, EarlyView.
Naroa Gimenez‐Camino +7 more
wiley +1 more source
Histone deacetylases and cancer [PDF]
Molecular Oncology, 2012 Reversible acetylation of histone and non‐histone proteins is one of the most abundant post‐translational modifications in eukaryotic cells. Protein acetylation and deacetylation are achieved by the antagonistic actions of two families of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs).
Maribel PARRA
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Current Opinion in Pharmacology, 2003
Post-translational modification of the histones of chromatin has a fundamental role in regulating gene expression. Enzymes involved in these epigenetic events include histone deacetylases (class I and class II), which can be inhibited by a structurally diverse group of small molecules.
Paul A, Marks +2 more
openaire +2 more sources
Post-translational modification of the histones of chromatin has a fundamental role in regulating gene expression. Enzymes involved in these epigenetic events include histone deacetylases (class I and class II), which can be inhibited by a structurally diverse group of small molecules.
Paul A, Marks +2 more
openaire +2 more sources
Histone deacetylase in neuropathology
2021Neuroepigenetics, a new branch of epigenetics, plays an important role in the regulation of gene expression. Neuroepigenetics is associated with holistic neuronal function and helps in formation and maintenance of memory and learning processes. This includes neurodevelopment and neurodegenerative defects in which histone modification enzymes appear to ...
Rohan, Gupta +2 more
openaire +2 more sources
Histone Deacetylase Inhibitors
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Thomas A, Miller +2 more
openaire +2 more sources
Assays for Histone Deacetylases
Current Topics in Medicinal Chemistry, 2009Epigenetics is defined as heritable changes in gene expression, i.e. the presentation of a certain phenotype, without alterations to the genetic code. This is a central phenomenon in developmental biology but also for the pathogenesis of a variety of diseases, e.g. for cancer in the case of silencing of tumor suppressor proteins.
Hauser, Alexander-Thomas +2 more
openaire +2 more sources
2008
Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three ...
+6 more sources
Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three ...
+6 more sources
Histone deacetylases and atherosclerosis
Atherosclerosis, 2015Atherosclerosis is the most common pathological process that leads to cardiovascular diseases, a disease of large- and medium-sized arteries that is characterized by a formation of atherosclerotic plaques consisting of necrotic cores, calcified regions, accumulated modified lipids, smooth muscle cells (SMCs), endothelial cells, leukocytes, and foam ...
Xia-xia, Zheng +4 more
openaire +2 more sources
Histone deacetylase inhibitors
European Journal of Medicinal Chemistry, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire +2 more sources
Histone Deacetylase Inhibitors
2004The base sequence of DNA provides the genetic code for proteins. The regulation of expression or suppression of gene transcription is largely determined by the structure of the chromatin--referred to as epigenetic gene regulation (Agalioti et al., 2002; Jenuwein and Allis, 2001; Richards and Elgin, 2002; Spotswood and Turner, 2002; Zhang and Reinberg ...
Paul A, Marks +3 more
openaire +2 more sources