Results 221 to 230 of about 51,098 (257)

Carbamazepine is an inhibitor of histone deacetylases

Life Sciences, 2005
Carbamazepine (CBZ) is a common antiepileptic drug (AED) that acts through multiple mechanisms including blockade and potentiation of cation channels and modulation of neurotransmitter levels. Whether it affects any component of the gene transcription machinery is unknown.
Andreas S, Beutler, SiDe, Li, Rebekka, Nicol, Martin J, Walsh   +3 more
openaire   +2 more sources

Selective Histone Deacetylase Inhibitors

Anti-Cancer Agents in Medicinal Chemistry, 2012
Histone deacetylases (HDACs) are a family of conserved metalloproteases which play a key role in the development of cancer. They can be divided into 18 subtypes according to their structural diversity. Histone deacetylase inhibitors are considered as potential anti-cancer agents and a lot of pan-HDAC inhibitors have entered clinical trials.
Huili, Pan, Jiangying, Cao, Wenfang, Xu
openaire   +2 more sources

Characterization of pea histone deacetylases

Plant Molecular Biology, 1988
The present paper is the first report on histone deacetylases from plants. Three enzyme fractions with histone deacetylase activity (HD0, HD1 and HD2) have been partially purified from pea (Pisum sativum) embryonic axes. They deacetylate biologically acetylated chicken histones and, to a lesser extent, chemically acetylated histones, this being a ...
R, Sendra, I, Rodrigo, M L, Salvador, L, Franco   +3 more
openaire   +2 more sources

The Human Histone Deacetylase Family

Experimental Cell Research, 2001
Since the identification of the first histone deacetylase (Taunton et al., Science 272, 408-411), several new members have been isolated. They can loosely be separated into entities on the basis of their similarity to various yeast histone deacetylases. The first class is represented by its closeness to the yeast Rpd3-like proteins, and the second most
S G, Gray, T J, Ekström
openaire   +2 more sources

Histone Deacetylases

Histone deacetylases (HDAC) are enzymes that regulate biological activity through removal of acetyl groups from histones and non-histone proteins. A few HDAC inhibitors have been approved for use as anti-cancer agents, but their clinical uptake so far has been limited, presumably due to their adverse effect profiles.
Shunsheng Zheng, Wojciech Barczak, Geng Liu, Nicholas La Thangue   +3 more
openaire   +1 more source

Histone Deacetylases, the Erasers of the Code

2016
The acetylation of the N-terminal tail domains of core histones provides a rich potential source of epigenetic information. Acetylation involves the addition of an acetyl group to a lysine residue by the action of the histone/lysine acetyltransferase enzymes (HATs/KATs).
Lamberti, María Julia, Vera, Renzo Emanuel, Rumie Vittar, Natalia Belen, Schneider, Gunter   +3 more
openaire   +2 more sources

Histone Deacetylase Activity Assay

2009
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from the epsilon-amino groups of conserved lysine residues in the amino terminal tail of histones. In humans, there are 18 potential deacetylase enzymes that are responsible for the removal of acetyl groups and maintenance of the equilibrium of lysine acetylation on ...
Zhigang, Yuan, Natalie, Rezai-Zadeh, Xiaohong, Zhang, Edward, Seto   +3 more
openaire   +2 more sources

Inhibitors of Histone-deacetylases

Tumori Journal, 2001
openaire   +3 more sources

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Genes, 2020
Giorgio Milazzo, Daniele Mercatelli, Piergiuseppe De Rosa   +2 more
exaly  

Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy

Cancers, 2020
Flavia Alves Verza, Ana Lucia Fachin, Jonathan R Dimmock   +2 more
exaly