Results 191 to 200 of about 82,781 (305)

Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signaling. [PDF]

Front Endocrinol (Lausanne)
Son Y, Byeon HE, Choi SE, Kim Y, Heo YJ, Kwon SB, Choi J, Han SJ, Jeon J, Kim HJ, Lee N, Lee KW.   +11 more
europepmc   +1 more source

Histone deacetylase 6 (HDAC6); histone deacetylase 8 (HDAC8) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Histone Deacetylases in Neurodegenerative Diseases and Their Potential Role as Therapeutic Targets: Shedding Light on Astrocytes. [PDF]

Pharmaceuticals (Basel)
Pinheiro PSM, Diniz LP, Franco LS, Siqueira M, Gomes FCA.   +4 more
europepmc   +1 more source

Using hybrid transcription factors to study gene function in rice. [PDF]

, 2015
Bian, Ming-Di, Li, Hong-Yu, Lin, ChenTao, Lin, Jian-Zhong, Liu, Bin, Liu, Jun, Peng, Yu-Chong, Zhang, Chun-Yu, Zhang, Yong-Xing, Zhao, Tao   +9 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Inhibition of Histone Deacetylases Induces Cancer Cell Apoptosis Through the PERK Pathway of ER Stress Response. [PDF]

J Cell Mol Med
Wang X, Yang C, Yang Y, Xu F, Yuan D, Gu Y.   +5 more
europepmc   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Epigenetic Histone Deacetylases Activity Assay in the Brain and Peripheral Organ Tissues. [PDF]

Curr Protoc
Reddy DS, Boyd H, Karnati V, Kim J, Ramakrishnan S, Wu X.   +5 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source