Results 191 to 200 of about 28,454 (236)

Mechanism of histone demethylase KDM5A in osteoporotic fracture healing through epigenetic regulation of the miR-495/SKP2/Runx2 axis. [PDF]

Mol Med
Li Z, Zhang J, Xu T, Hao Z, Li Y.
europepmc   +1 more source

Yam Carbon Dots Promote Bone Defect Repair by Modulating Histone Demethylase 4B. [PDF]

Int J Nanomedicine
Chen Q, Liu S, Wang Y, Tong M, Sun H, Dong M, Lu Y, Niu W, Wang L.   +8 more
europepmc   +1 more source

JmjC domain-containing histone demethylase gene family in Chinese cabbage: Genome-wide identification and expressional profiling. [PDF]

PLoS One
Yin F, Hu Y, Cao X, Xiao X, Zhang M, Xiang Y, Wang L, Yao Y, Sui M, Shi W.   +9 more
europepmc   +1 more source

Histone demethylase inhibitor KDM5-C70 regulates metabolomic and lipidomic programming during an astrocyte differentiation of rat neural stem cell. [PDF]

Sci Rep
Shim M, San TT, Shin B, Lee H, Han SB, Lee DK, Kim HJ.   +6 more
europepmc   +1 more source

Targeting N-Methyl-lysine Histone Demethylase KDM4 in Cancer: Natural Products Inhibitors as a Driving Force for Epigenetic Drug Discovery. [PDF]

ChemMedChem
Cursaro I, Milioni L, Eslami K, Sirous H, Carullo G, Gemma S, Butini S, Campiani G.   +7 more
europepmc   +1 more source

The KDM6 histone demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells

Cribbs AP, Hookway ES, Yapp C, Che K, Dunford JE, Gutheridge K, Lari F, Wells G, Philpott M, Cain P, Brotherton D, Palmer C, Maret W, Fitzgibbons J, Christianson JC, Oppermann U.   +15 more
europepmc   +1 more source

Correction to: ETHYLENE INSENSITIVE3/EIN3-LIKE1 modulate FLOWERING LOCUS C expression via histone demethylase interaction. [PDF]

Plant Physiol
europepmc   +1 more source

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Inhibitors of histone demethylases

Bioorganic & Medicinal Chemistry, 2011
Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared.
Lohse, Brian, Kristensen, Jesper L, Kristensen, Line H, Agger, Karl, Helin, Kristian, Gajhede, Michael, Clausen, Rasmus P   +6 more
openaire   +3 more sources

In Vitro Histone Demethylase Assays

2022
Dynamic histone methylation regulates gene activation and repression. It is involved in proliferation, differentiation, lineage specification, and development. Histone demethylase assays are invaluable in studying histone demethylation substrate recognition, kinetics, regulation, and inhibition by small molecules, many of which are potential ...
openaire   +2 more sources

Recent Progress in Histone Demethylase Inhibitors

Journal of Medicinal Chemistry, 2016
There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of probes for target exploration and for therapeutic purposes. Here we update on previous reviews on the inhibition of the lysine-specific demethylases (LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC
McAllister, Tom E.; England, Katherine S.; Hopkinson, Richard J.; Brennan, Paul E.; Kawamura, Akane; Schofield, Christopher J.   +6 more
openaire   +2 more sources