Results 101 to 110 of about 197,157 (312)

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence [PDF]

, 2012
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest.
Aksoy, O., Bernstein, E., Chicas, A., Evertts, A. G., Garcia, B. A., Kapoor, A., Lowe, S. W., Wang, X. W., Zhang, M. Q.   +8 more
core   +1 more source

Targeting Histone Demethylases in Cancer Therapy [PDF]

Clinical Cancer Research, 2009
Abstract A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone methylation and gene re-expression. It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase inhibitors may represent a valuable addition ...
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Comprehensive Bioinformatics Analysis of Key Methyltransferases and Demethylases for Histone Lysines in Hepatocellular Carcinoma

Technology in Cancer Research & Treatment, 2020
Background & Aims: Methylation of lysines on histones, controlled by various methyltransferases and demethylases, is an important component of epigenetic modifications, and abnormal regulation of such enzymes serves as common events in hepatocellular ...
Yang Zheng PhD, Lili Tang, Guojiang Chen PhD, Ziling Liu PhD   +3 more
doaj   +1 more source

Epigenetic therapy in urologic cancers: an update on clinical trials [PDF]

, 2016
Epigenetic dysregulation is one of many factors that contribute to cancer development and progression. Numerous epigenetic alterations have been identified in urologic cancers including histone modifications, DNA methylation changes, and microRNA ...
Agarwal, Aggarwal, Alon, Anant, Arbor, Bassi, Bastian, Bates, Baylin, Benevolenskaya, Bologna, Borden, Burris, Cairns, Cairns, Carducci, Carducci, Catto, Chi, Clark, Clark, Cole, Croce, Croce, Dahiya, Dahiya, de Balincourt, de Bono, de Bono, Domingos, Dorr, Ehtejab, Eisen, Eisenberger, Eisenberger, Eisenhauer, Eisenhauer, Ekström, Ellinger, Ferrari, Festuccia, Fuessel, Fuessel, Gleave, Grant, Gregory, Griffiths, Han, Harland, Heinrich, Helin, Helin, Hennenlotter, Hsiao, Huang, Hussain, Investigators, Investigators, Issa, Jemal, Jeronimo, Jones, Kiltie, Kim, Kim, Kouzarides, Kouzarides, Kristiansen, Kristiansen, Liang, Liang, Lin, Lyko, Maitland, Manoharan, Marks, Martel, Martell, Meeran, Muller, Nelson, Ochiya, Ogawa, Osman, Pectasides, Pili, Pili, Pompidou, Ren, Rudek, Sartor, Sawyers, Schellhammer, Scher, Sediqe, Shariat, Shi, Sidransky, Sukumar, Tewari, Tolcher, Tolcher, Torti, Verma, Verma, Visakorpi, Von Hoff, Von Ruecker, Wilding, Winquist, Wu, Ørntoft   +111 more
core   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

HERVs, transposons and human diseases : part 3 [PDF]

, 2012
Part 1 and 2 of this article can be found through theses links: https://www.um.edu.mt/library/oar//handle/123456789/12961 https://www.um.edu.mt/library/oar//handle/123456789/13012Part 3 of the article.
Baldacchino, Sandra, Grech, Alfred
core   +1 more source

Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. [PDF]

, 2017
BACKGROUND: Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activation.
Brock, Hugh W, Hodgson, Jacob W, Li, Taosui, Mazo, Alexander, Petruk, Svetlana   +4 more
core   +2 more sources

LSD1 Histone Demethylase Assays and Inhibition [PDF]

, 2016
The lysine-specific demethylase (LSD1) is a flavin-dependent amine oxidase that selectively removes one or two methyl groups from histone H3 at the Lys4 position. Along with histone deacetylases 1 and 2, LSD1 is involved in epigenetically silencing gene expression. LSD1 has been implicated as a potential therapeutic target in cancer and other diseases.
D, Hayward, P A, Cole
openaire   +2 more sources