Results 111 to 120 of about 27,890 (158)

Crosstalk between epigenetics and metabolism-Yin and Yang of histone demethylases and methyltransferases in cancer. [PDF]

Brief Funct Genomics, 2017
Filipp FV.
europepmc   +1 more source

Histone Demethylase KDM4A Regulates Histone Demethylation during Adipogenesis

Histone Demethylase KDM4A Regulates Histone Demethylation during Adipogenesis
学位の種別: 課程博士 審査委員会委員 : （主査）東京大学教授 酒井 寿郎, 東京大学教授 児玉 龍彦, 東京大学特任教授 田中 十志也, 東京大学教授 油谷 浩幸, 東京大学教授 栗原 ...
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Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B. [PDF]

Molecules, 2019
Pippa S, Mannironi C, Licursi V, Bombardi L, Colotti G, Cundari E, Mollica A, Coluccia A, Naccarato V, La Regina G, Silvestri R, Negri R.   +11 more
europepmc   +1 more source

The Emerging Role of Histone Demethylases in Renal Cell Carcinoma. [PDF]

J Kidney Cancer VHL, 2017
Guo X, Zhang Q.
europepmc   +1 more source

Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases. [PDF]

Mol Med Rep, 2018
Li X, Moon G, Shin S, Zhang B, Janknecht R.   +4 more
europepmc   +1 more source

Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. [PDF]

Biomed Res Int, 2016
Rosales W, Carulla J, García J, Vargas D, Lizcano F.   +4 more
europepmc   +1 more source

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Inhibitors of histone demethylases

Bioorganic & Medicinal Chemistry, 2011
Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared.
Lohse, Brian, Kristensen, Jesper L, Kristensen, Line H, Agger, Karl, Helin, Kristian, Gajhede, Michael, Clausen, Rasmus P   +6 more
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In Vitro Histone Demethylase Assays

2022
Dynamic histone methylation regulates gene activation and repression. It is involved in proliferation, differentiation, lineage specification, and development. Histone demethylase assays are invaluable in studying histone demethylation substrate recognition, kinetics, regulation, and inhibition by small molecules, many of which are potential ...
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Recent Progress in Histone Demethylase Inhibitors

Journal of Medicinal Chemistry, 2016
There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of probes for target exploration and for therapeutic purposes. Here we update on previous reviews on the inhibition of the lysine-specific demethylases (LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC
McAllister, Tom E.; England, Katherine S.; Hopkinson, Richard J.; Brennan, Paul E.; Kawamura, Akane; Schofield, Christopher J.   +6 more
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In Vitro Histone Demethylase Assays

2015
Histone methylation plays pivotal roles in modulating chromatin structure and dynamics and in turn regulates genomic processes that require access to the DNA template. The methylation status at different sites is dynamically regulated by histone methyltransferases and demethylases. During the past decade, two classes of proteins have been characterized
Kenji, Kokura, Lidong, Sun, Jia, Fang
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