Results 131 to 140 of about 19,155 (194)

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases. [PDF]

Mol Cancer Ther, 2021
Hoyle RG, Wang H, Cen Y, Zhang Y, Li J.
europepmc   +1 more source

Inhibition of Jumonji Histone Demethylases Selectively Suppresses HER2⁺ Breast Leptomeningeal Carcinomatosis Growth via Inhibition of GMCSF Expression. [PDF]

Cancer Res, 2021
Bhan A, Ansari KI, Chen MY, Jandial R.
europepmc   +1 more source

JIB-04, a Pan-Inhibitor of Histone Demethylases, Targets Histone-Lysine-Demethylase-Dependent AKT Pathway, Leading to Cell Cycle Arrest and Inhibition of Cancer Stem-Like Cell Properties in Hepatocellular Carcinoma Cells. [PDF]

Int J Mol Sci, 2022
Lee J, Kim JS, Cho HI, Jo SR, Jang YK.
europepmc   +1 more source

Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality.

Cell Rep, 2021
Zaghet N, Madsen K, Rossi F, Perez DF, Amendola PG, Demharter S, Pfisterer U, Khodosevich K, Pasini D, Salcini AE.   +9 more
europepmc   +1 more source

The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets. [PDF]

Mol Biomed
Hong Y, Guo H, Chen Q, Yu C.
europepmc   +1 more source

Features of the PHF8/KIAA1718 histone demethylase [PDF]

Cell Research, 2010
Tamaki, Suganuma, Jerry L, Workman
openaire   +2 more sources

Current advances and future directions in targeting histone demethylases for cancer therapy. [PDF]

Mol Cells
Shin JH, Yoo HB, Roe JS.
europepmc   +1 more source

Methylstat sensitizes ovarian cancer cells to PARP-inhibition by targeting the histone demethylases JMJD1B/C. [PDF]

Cancer Gene Ther
Schwarz FM, Klotz DM, Yang R, Brux M, Buchholz F, Harb H, Link T, Wimberger P, Theis M, Kuhlmann JD.   +9 more
europepmc   +1 more source

Analogue-Sensitive Inhibition of Histone Demethylases Uncovers Member-Specific Function in Ribosomal Protein Synthesis. [PDF]

J Am Chem Soc
Kuwik J, Scott V, Chedid S, Stransky S, Hinkelman K, Kavoosi S, Calderon M, Watkins S, Sidoli S, Islam K.   +9 more
europepmc   +1 more source