Results 111 to 120 of about 197,157 (312)
Jumonji family histone demethylases in neural development [PDF]
Cell and Tissue Research, 2014 Central nervous system (CNS) development is driven by coordinated actions of developmental signals and chromatin regulators that precisely regulate gene expression patterns. Histone methylation is a regulatory mechanism that controls transcriptional programs.
Fueyo, Raquel +2 more
openaire +3 more sources
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
Reader domain specificity and lysine demethylase-4 family function
Nature Communications, 2016 KDM4 histone demethylases target specific chromatin regions by a mechanism that is not fully characterised. Here, the authors identify trimethyl-lysine histone-binding preferences for closely related KDM4 double tudor domains and use structural and ...
Zhangli Su +14 more
doaj +1 more source
Nature Communications, 2021 Accumulating evidences point to a discrepancy in the epigenetic behaviour of transgenes and endogenous genes. Here, via characterization of mutants impaired in histone demethylases JMJ14 and IBM1, the authors show that transgenes and endogenous genes are
Nicolas Butel +11 more
doaj +1 more source
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance [PDF]
, 2023 Fei Li +18 more
openalex +1 more source
Advanced Science, EarlyView.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
wiley +1 more source
Intrinsic protein disorder in histone lysine methylation [PDF]
, 2016 Histone lysine methyltransferases (HKMTs), catalyze mono-, di- and trimethylation of lysine residues, resulting in a regulatory pattern that controls gene expression.
Horvath, T. +6 more
core +1 more source
Identification of Histone Demethylases in Saccharomyces cerevisiae [PDF]
Journal of Biological Chemistry, 2007 Based on the prediction that histone lysine demethylases may contain the JmjC domain, we examined the methylation patterns of five knock-out strains (ecm5Delta, gis1Delta, rph1Delta, jhd1Delta, and jhd2Delta (yjr119cDelta)) of Saccharomyces cerevisiae.
Shengjiang, Tu +11 more
openaire +2 more sources
Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins
Advanced Science, EarlyView.Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang +3 more
wiley +1 more source
KDM2 family members are regulated by HIF-1 in hypoxia. [PDF]
, 2017 Hypoxia is not only a developmental cue but also a stress and pathological stimulus in many human diseases. The response to hypoxia at the cellular level relies on the activity of the transcription factor family, hypoxia inducible factor (HIF).
Batie, Michael +3 more
core +4 more sources