Results 161 to 170 of about 197,157 (312)

Development of Homogeneous Nonradioactive Methyltransferase and Demethylase Assays Targeting Histone H3 Lysine 4 [PDF]

, 2011
Nancy Gauthier, Mireille Caron, Liliana Pedro, Mathieu Arcand, Julie Blouin, Anne Labonté, Claire Normand, Valérie E. Paquet, Anja Rodenbrock, Marjolaine Roy, Nathalie Rouleau, Lucille Beaudet, Jaime Padrós, Roberto Rodrı́guez-Suárez   +13 more
openalex   +1 more source

Crucial Role of Lysine-Specific Histone Demethylase 1 in RANKL-Mediated Osteoclast Differentiation [PDF]

, 2023
Mina Ding, Zhihao Chen, Eunjin Cho, Sang-Wook Park, Tae‐Hoon Lee   +4 more
openalex   +1 more source

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells

Journal of Biological Chemistry, 2018
Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and elimination of stressed, transformed, or virus-infected cells. They critically shape the inflammatory cytokine environment to orchestrate interactions of cells of the ...
A. Cribbs, E. Hookway, G. Wells, M. Lindow, S. Obad, H. Oerum, R. Prinjha, N. Athanasou, A. Sowman, M. Philpott, H. Penn, K. Soderstrom, M. Feldmann, U. Oppermann   +13 more
semanticscholar   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Histone Lys demethylase KDM3C demonstrates anti‐inflammatory effects by suppressing NF‐κB signaling and osteoclastogenesis [PDF]

, 2019
Jae Young Lee, Shebli Mehrazarin, Abdullah Alshaikh, Sol Kim, Wei Chen, Renate Lux, Yousang Gwack, Reuben H. Kim, Mo Kang   +8 more
openalex   +1 more source

Uncovering the Genetic Landscape of Spinal Dysraphism: A Retrospective Analysis of 150 Fetal Cases

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Spinal dysraphism (SD) results from incomplete neural tube closure and encompasses a heterogeneous group of congenital anomalies with genetic and environmental etiologies. Although genetic contributions are recognized, causative variants remain insufficiently defined, and the clinical implications of extended genetic testing on ...
I. Bedei, A. Feresin, R. Zemet, D. Berner, D. Polidori, K. Fröbius, A. Skakkebæk, R. Axt‐Fliedner, M. Shoukier, C. Keil   +9 more
wiley   +1 more source

Histone lysine demethylases in mammalian embryonic development

Experimental &Molecular Medicine, 2017
Post-translational modifications, such as methylation, acetylation and phosphorylation, of histone proteins play important roles in regulating dynamic chromatin structure.
Hongjie Shen, Wenqi Xu, Fei Lan
semanticscholar   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor

Nature Communications, 2019
Jumonji domain-containing histone demethylases regulate flowering in plants. Here Zheng et al. show that Arabidopsis JMJ13 is an H3K27me3 demethylase that recognizes H3K27me3 via hydrogen bonding and hydrophobic interactions and affects both photoperiod ...
Shuzhi Zheng, Hongmiao Hu, Huimin Ren, Zhenlin Yang, Qi Qiu, Weiwei Qi, Xinye Liu, Xiaomei Chen, Xiekui Cui, Sisi Li, Bing Zhou, Daye Sun, Xiaofeng Cao, Jiamu Du   +13 more
doaj   +1 more source

The Jumonji-C Histone Lysine Demethylase KDM3B Senses Cellular Iron to Regulate Anabolism Through mTORC1

, 2021
Jason Shapiro, Hsiang‐Chun Chang, Zibo Zhao, Justin Geier, Elizabeth T. Bartom, Chunlei Chen, Yihan Chen, Adam De Jesus, Zohra Sattar, Farnaz Keyhani‐Nejad, Tatsuya Sato, Lucía Ramos-Alonso, Antonia María Romero, María Teresa Martínez‐Pastor, Shang-chuan Jiang, Shiv K. Sah‐Teli, Liming Li, David J. Bentrem, Gary D. Lopaschuk, Issam Ben‐Sahra, Thomas V. O’Halloran, Ali Shilatifard, Sergi Puig, Joy Bergelson, Peppi Koivunen, Hossein Ardehali   +25 more
openalex   +1 more source