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The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.
Blood, 2019 Agger K +5 more
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Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. [PDF]
Biomed Res Int, 2016 Rosales W +4 more
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The emerging roles of histone demethylases in cancers
Cancer and Metastasis ReviewsModulation of histone methylation status is regarded as an important mechanism of epigenetic regulation and has substantial clinical potential for the therapy of diseases, including cancer and other disorders. The present study aimed to provide a comprehensive introduction to the enzymology of histone demethylases, as well as their cancerous roles ...
Dali Tong, Tong Dali
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Inhibitors of histone demethylases
Bioorganic & Medicinal Chemistry, 2011Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared.
Lohse, Brian +6 more
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Histone demethylases in development and disease
Trends in Cell Biology, 2010Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a
Pedersen, Marianne Terndrup +1 more
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The emerging functions of histone demethylases
Current Opinion in Genetics & Development, 2008Epigenetic information refers to heritable changes in gene function that are stable between cell divisions but which is not a result of changes in the DNA sequence. Part of the epigenetic mechanism has been ascribed to modifications of histones or DNA that affects the transcription of specific genes. In this context, post-translational modifications of
Agger, Karl +3 more
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JMJD6 Is a Histone Arginine Demethylase
Science, 2007Arginine methylation occurs on a number of proteins involved in a variety of cellular functions. Histone tails are known to be mono- and dimethylated on multiple arginine residues where they influence chromatin remodeling and gene expression. To date, no enzyme has been shown to reverse these regulatory modifications.
Bingsheng, Chang +3 more
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In Vitro Histone Demethylase Assays
2009Histone methylation plays important roles in chromatin structure, transcription, and epigenetic state of the cell. Tremendous discoveries recently demonstrated that methylation mark is not static but is dynamically regulated by both histone methyltransferases and the histone demethylases.
Kenji, Kokura, Jia, Fang
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In Vitro Histone Demethylase Assays
2022Dynamic histone methylation regulates gene activation and repression. It is involved in proliferation, differentiation, lineage specification, and development. Histone demethylase assays are invaluable in studying histone demethylation substrate recognition, kinetics, regulation, and inhibition by small molecules, many of which are potential ...
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In Vitro Histone Demethylase Assays
2015Histone methylation plays pivotal roles in modulating chromatin structure and dynamics and in turn regulates genomic processes that require access to the DNA template. The methylation status at different sites is dynamically regulated by histone methyltransferases and demethylases. During the past decade, two classes of proteins have been characterized
Kenji, Kokura, Lidong, Sun, Jia, Fang
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