Results 61 to 70 of about 40,662 (194)

Human SCNT Gets a Boost from Histone Demethylation [PDF]

Cell Stem Cell, 2015
Human somatic cell nuclear transfer (SCNT) holds great potential in regenerative medicine; however, its applicability has been limited by great variability in reprogramming efficiencies. A new study in this issue of Cell Stem Cell reports a simple way to expand human SCNT to hard-to-reprogram oocytes (Chung et al., 2015).
Deglincerti, Alessia, Brivanlou, Ali H.
openaire   +2 more sources

Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes

Cell Reports, 2017
At fertilization, the paternal genome undergoes extensive reprogramming through protamine-histone exchange and active DNA demethylation, but only a few maternal factors have been defined in these processes.
Yuki Hatanaka, Takeshi Tsusaka, Natsumi Shimizu, Kohtaro Morita, Takehiro Suzuki, Shinichi Machida, Manabu Satoh, Arata Honda, Michiko Hirose, Satoshi Kamimura, Narumi Ogonuki, Toshinobu Nakamura, Kimiko Inoue, Yoshihiko Hosoi, Naoshi Dohmae, Toru Nakano, Hitoshi Kurumizaka, Kazuya Matsumoto, Yoichi Shinkai, Atsuo Ogura   +19 more
doaj   +1 more source

Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation. [PDF]

PLoS ONE, 2012
15-Lipoxygenase-1 (15-LOX-1) oxidizes polyunsaturated fatty acids to a rich spectrum of biologically active metabolites and is implicated in physiological membrane remodelling, inflammation and apoptosis.
Cheng Liu, Dawei Xu, Hongya Han, Yidong Fan, Frida Schain, Zhonghua Xu, Hans-Erik Claesson, Magnus Björkholm, Jan Sjöberg   +8 more
doaj   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Sleep and Neurochemical Modulation by DZNep and GSK-J1: Potential Link With Histone Methylation Status

Frontiers in Neuroscience, 2019
Histone methylation/demethylation plays an important modulatory role in chromatin restructuring, RNA transcription and is essential for controlling a plethora of biological processes.
Eric Murillo-Rodríguez, Eric Murillo-Rodríguez, Gloria Arankowsky-Sandoval, Jorge Aparecido Barros, Jorge Aparecido Barros, Nuno Barbosa Rocha, Nuno Barbosa Rocha, Tetsuya Yamamoto, Tetsuya Yamamoto, Sérgio Machado, Sérgio Machado, Henning Budde, Henning Budde, Henning Budde, Diogo Telles-Correia, Diogo Telles-Correia, Diogo Monteiro, Diogo Monteiro, Diogo Monteiro, Luis Cid, Luis Cid, Luis Cid, André Barciela Veras, André Barciela Veras   +23 more
doaj   +1 more source

Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice

Advanced Science, EarlyView.
This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang, Zhengting Chen, Pengxiang Bai, Biao Liu, Lingling Meng, Jian Zhang, Xu Li, Dao‐Xiu Zhou, Xuan Ma, Yu Zhao   +9 more
wiley   +1 more source

Recognition of Histone H3K4 Trimethylation by the Plant Homeodomain of PHF2 Modulates Histone Demethylation [PDF]

Journal of Biological Chemistry, 2010
Distinct lysine methylation marks on histones create dynamic signatures deciphered by the "effector" modules, although the underlying mechanisms remain unclear. We identified the plant homeodomain- and Jumonji C domain-containing protein PHF2 as a novel histone H3K9 demethylase.
Hong, Wen, Jingzhi, Li, Tanjing, Song, Ming, Lu, Pu-Yeh, Kan, Min Gyu, Lee, Bingdong, Sha, Xiaobing, Shi   +7 more
openaire   +2 more sources

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Histone demethylase KDM4B epigenetically controls NLRP3 expression to enhance inflammatory responses

EMBO Molecular Medicine
NLRP3 inflammasome, the archetypical molecular driver of inflammation, plays crucial roles in host defense and maintaining cellular homeostasis. Demethylation of histone 3 lysine 9 trimethylation (H3K9me3, the repressive mark for euchromatic genes) is ...
Li Tong, Hui Song, Yuan Gao, Danhui Qin, Caiwei Wang, Qi Li, Yue Fu, Chunyuan Zhao, Zhendong Ying, Dailing Chen, Chengjiang Gao, Chaofeng Han, Wei Zhao, Ying Qin, Lei Zhang   +14 more
doaj   +1 more source

HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. [PDF]

PLoS ONE, 2012
The KDM4 subfamily of JmjC domain-containing demethylases mediates demethylation of histone H3K36me3/me2 and H3K9me3/me2. Several studies have shown that human and yeast KDM4 proteins bind to specific gene promoters and regulate gene expression. However,
Chia-Hui Lin, Ariel Paulson, Susan M Abmayr, Jerry L Workman   +3 more
doaj   +1 more source