ARID1A regulates histone octamer transfer activity of human canonical BAF complex. [PDF]
Nucleic Acids ResMoro N, Fujisawa-Tanaka Y, Watanabe S.
europepmc +3 more sources
Regulation of Transcription through Acetylation of H3K122 on the Lateral Surface of the Histone Octamer [PDF]
Cell, 2013 Philipp Tropberger +11 more
openalex +2 more sources
Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF
bioRxiv, 2021 Nucleosome assembly requires the coordinated deposition of histone complexes H3-H4 and H2A-H2B to form a histone octamer on DNA. In the current paradigm, specific histone chaperones guide the deposition of first H3-H4 and then H2A-H2B(1–5). Here, we show
Ivan Corbeski +14 more
semanticscholar +1 more source
Abstract P-19: 15-Microsecond Molecular Dynamics Simulations of Nucleosome Show Structural Heterogeneity and Plasticity [PDF]
International Journal of Biomedicine, 2021 Background: Nucleosomes are basic units of chromatin organization, resembling spools with ~150 base pairs of DNA wrapped around the octamer of histone proteins. They play a crucial role in chromatin compactization and gene expression.
Grigoriy A. Armeev +4 more
doaj +1 more source
Molecular mechanism of UV damage modulation in nucleosomes
Computational and Structural Biotechnology Journal, 2022 Exposure to ultraviolet (UV) light causes the formation of mutagenic cyclobutane pyrimidine dimers (CPDs) in cellular DNA. Previous studies have revealed that CPD formation in nucleosomes, the building blocks of chromatin, shows a striking ∼10 base pair (
Bastian Stark +2 more
doaj +1 more source
Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility
Nature Communications, 2023 Here the authors show that H2A.Z histone variant incorporation reduces the nucleosomal barrier for transcription. Furthermore their simulations reveal that H2A.Z facilitates spontaneous DNA unwrapping from the histone octamer and enhances nucleosome ...
Shuxiang Li +2 more
doaj +1 more source
Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
Nature Communications, 2021 Nucleosomes tightly wrap ~147 DNA base pairs around an octamer of histone proteins, but how nucleosome structural dynamics affect genome functioning is not completely clear.
Grigoriy A. Armeev +4 more
doaj +1 more source
Octamer reconstitution from acid‐extracted chicken erythrocyte histones [PDF]
FEBS Letters, 1983 Histone octamers have been reconstituted from acid‐extracted chicken erythrocyte histones. By the criteria of molecular size on exclusion chromatography as well as sedimentation velocity and conformational properties established by circular dichroism, fluorescence spectroscopy and imido‐ester cross‐linking, the reconstituted octamers have a structure ...
Lindsey, George G. +4 more
openaire +2 more sources
The Histone Modifications of Neuronal Plasticity
Neural Plasticity, 2021 Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation ...
Huixia Geng +3 more
doaj +1 more source
A Horizontal Magnetic Tweezers for Studying Single DNA Molecules and DNA-Binding Proteins
Molecules, 2021 We report data from single molecule studies on the interaction between single DNA molecules and core histones using custom-designed horizontal magnetic tweezers.
Roberto Fabian +5 more
doaj +1 more source