Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals [PDF]
Cells, 2020 The systematic mutation of histone 3 (H3) genes in model organisms has proven to be a valuable tool to distinguish the functional role of histone residues.
Matteo Trovato +3 more
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Implications of canonical histone H3.1 and histone variant H3.3 in cancer [PDF]
Open BiologyHistones are the fundamental building blocks of chromatin and serve as pivotal regulators of gene expression. Differential expression and mutations of H3.1 and H3.3 genes have been implicated in the pathogenesis of various cancer types. Mutations in H3.3,
Peng Wu, Li Wang, Ting Wen, Qiao Yi Chen
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Plasma cell differentiation is regulated by the expression of histone variant H3.3 [PDF]
Nature CommunicationsThe differentiation of B cells into plasma cells is associated with substantial transcriptional and epigenetic remodeling. H3.3 histone variant marks active chromatin via replication-independent nucleosome assembly.
Yuichi Saito +10 more
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Maintenance of cell fates and regulation of the histone variant H3.3 by TLK kinase in Caenorhabditis elegans [PDF]
Biology Open, 2019 Cell-fate maintenance is important to preserve the variety of cell types that are essential for the formation and function of tissues. We previously showed that the acetylated histone-binding protein BET-1 maintains cell fate by recruiting the histone ...
Yukimasa Shibata +2 more
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Phosphorylation-mimicking histone H3.3 rescues exercise-induced gene responses in an epigenetic aging model of mouse skeletal muscle [PDF]
Laboratory Animal ResearchBackground With aging, the canonical histone H3.1/3.2 in skeletal muscle is progressively replaced by the non-canonical variant H3.3. Although H3.3 is thought to be involved in age-related epigenetic regulation due to its role as a histone variant, its ...
Sho Maruyama, Fuminori Kawano
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Local nuclear to cytoplasmic ratio regulates H3.3 incorporation via cell cycle state during zygotic genome activation [PDF]
EMBO ReportsEarly embryos often have unique chromatin states prior to zygotic genome activation (ZGA). In Drosophila, ZGA occurs after 13 reductive nuclear divisions during which the nuclear to cytoplasmic (N/C) ratio grows exponentially.
Anusha D Bhatt +4 more
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PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback [PDF]
Nature CommunicationsCircadian rhythms in gene expression are coincident with 24 hr dynamics in the recruitment of the core-clock transcription factor heterodimer CLOCK-BMAL1 to chromatin.
Dominika Letkova +5 more
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HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to
Epigenetics & Chromatin, 2012 Background Nuclear reprogramming is potentially important as a route to cell replacement and drug discovery, but little is known about its mechanism. Nuclear transfer to eggs and oocytes attempts to identify the mechanism of this direct route towards ...
Jullien Jerome +5 more
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Daxx-Dependent H3.3 Deposition Promotes Double-Strand Breaks Repair by Homologous Recombination [PDF]
CellsDNA double-strand breaks (DSBs) can be induced by cellular byproducts or genotoxic agents. Improper processing of these lesions leads to increased genome instability, which constitutes a hallmark of pathological conditions and fuels carcinogenesis.
Laura Zannini +3 more
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Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice. [PDF]
PLoS Genetics, 2015 Histones package DNA and regulate epigenetic states. For the latter, probably the most important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3.
Michelle C W Tang +11 more
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