Results 101 to 110 of about 8,454 (206)

Telomere–metabolism–immunity axis in sarcoma: Immune evasion mechanisms and therapeutic strategies

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
Telomere maintenance mechanisms (telomerase reverse transcriptase and alternative lengthening of telomeres) reprogram metabolism and dampen innate immune sensing in sarcomas. Metabolic rewiring (glutamine addiction, glycolysis and fatty acid oxidation) fosters T‐cell dysfunction and myeloid‐derived suppressor cell accumulation.
Ji‐Yong Sung, June Hyuk Kim
wiley   +1 more source

Application of Recombination -Induced Tag Exchange (RITE) to study histone dynamics in human cells

Epigenetics, 2020
In eukaryotes, nucleosomes form a barrier to DNA templated reactions and must be dynamically disrupted to provide access to the genome. During nucleosome (re)assembly, histones can be replaced by new histones, erasing post-translational modifications ...
Thom M. Molenaar, Marc Pagès-Gallego, Vanessa Meyn, Fred van Leeuwen   +3 more
doaj   +1 more source

A single N-terminal amino acid determines the distinct roles of histones H3 and H3.3 in the Drosophila male germline stem cell lineage.

PLoS Biology, 2023
Adult stem cells undergo asymmetric cell divisions to produce 2 daughter cells with distinct cell fates: one capable of self-renewal and the other committed for differentiation.
Chinmayi Chandrasekhara, Rajesh Ranjan, Jennifer A Urban, Brendon E M Davis, Wai Lim Ku, Jonathan Snedeker, Keji Zhao, Xin Chen   +7 more
doaj   +1 more source

RNA-binding activity of the rat calmodulin-binding PEP-19 protein and of the long PEP-19 isoform [PDF]

, 2012
Synthesis of H1\u2da histone protein, in the developing rat brain, seems to be regulated mainly at the post-transcriptional level. Since regulation of RNA metabolism depends on a series of RNA-binding proteins, we have been searching for RNA-binding ...
DI LIEGRO, C., DI LIEGRO, I., Lo Cicero, A., Proia, P., Sala, A., Saladino, P., Schiera, G.   +6 more
core   +1 more source

Epigenetic and replacement roles of histone variant H3.3 in reproduction and development

The International Journal of Developmental Biology, 2009
The nucleosomal organization of eukaryotic chromatin is generally established during DNA replication by the deposition of canonical histones synthesized in S phase. However, cells also use a Replication Independent (RI) nucleosome assembly pathway that allows the incorporation of non-canonical histone variants in the chromatin.
Orsi, Guillermo A, Couble, Pierre, Loppin, Benjamin   +2 more
openaire   +3 more sources

The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner [PDF]

, 2012
This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.[Background]: CTCF is a highly conserved and essential zinc finger protein expressed in virtually all cell types. In conjunction with cohesin,
Delgado, M. Dolores, Galjart, Niels, Rosa-Garrido, Manuel, Sleutels, Frank   +3 more
core   +2 more sources

Epigenetic control of cell identities from epiblast to gastrulation

The FEBS Journal, Volume 292, Issue 20, Page 5259-5287, October 2025.
In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley   +1 more source

Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN [PDF]

, 2013
Children and young adults with glioblastoma (GBM) have a median survival rate of only 12 to 15 months, and these GBMs are clinically and biologically distinct from histologically similar cancers in older adults.
Ashworth, A, Bajrami, I, Barretos Cancer Hosp, Bax, D A, Bjerke, L, Burford, A, Carvalho, D, Coimbra, Hargrave, D, Inst Cancer Research, Jones, C, Jury, A, Lord, C J, Mackay, A, McGonnell, I M, Minho, Nandhabalan, M, Popov, S, Reis, R M, Taylor, K R, UCL, Vinci, M, Workman, P   +22 more
core   +2 more sources

What Epigenetics Teaches Us About Neuron–Glioma Interactions

BioEssays, Volume 47, Issue 9, September 2025.
Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense and respond to neural signals. Targeting the epigenetic machinery that facilitates this neuron–glioma crosstalk provides a strategy to disrupt the neural ...
Chaitali Chakraborty, Itzel Nissen, Silvia Remeseiro   +2 more
wiley   +1 more source

Exploring the Potential of Tsuruazuki Bean as a Functional Food to Curb Obesity Using Human Amniotic Epithelial Cells and 3T3‐L1 Preadipocytes

Food Frontiers, Volume 6, Issue 5, Page 2359-2375, September 2025.
Obesity is a global health problem that requires research and regulatory attention. This research aims to investigate transcriptome‐wide changes induced by Vigna umbellata (Tsuruazuki) using a stem cell‐based tool and preadipocytes to explore its untapped potential as a functional food for anti‐obesity applications.
Elda Nurafnie Ibnu Rasid, Farhana Ferdousi, Kazunori Sasaki, Kyoko Toda, Shinya Takahashi, Mari Maeda‐Yamamoto, Hiroko Isoda   +6 more
wiley   +1 more source