Nature Communications, 2018 The HIRA histone chaperone complex is involved in the deposition of the histone variant H3.3. Here the authors, by using biochemical and crystallographic approaches, report the homotrimerization of the HIRA subunit which is critical for the functional ...
Dominique Ray-Gallet +7 more
doaj +1 more source
The Histone Deacetylase Complex (HDC) 1 protein of Arabidopsis thaliana has the capacity to interact with multiple proteins including histone 3-binding proteins and histone 1 variants [PDF]
, 2016 Intrinsically disordered proteins can adopt multiple conformations thereby enabling interaction with a wide variety of partners. They often serve as hubs in protein interaction networks. We have previously shown that the Histone Deacetylase Complex (HDC)
Amtmann, Anna +6 more
core +1 more source
Advanced Genetics, Volume 6, Issue 3, September 2025.The article explores how the 3D structure of DNA governs stem cell fate. Key architectural elements and advanced tools are described revealing dynamic genome organization. The work links spatial genome changes to precise gene control during cell differentiation.
Yanchi He +12 more
wiley +1 more source
Insight into the pathogenesis and nature of Central giant cell lesions of the jaws [PDF]
, 2015 Central giant cell lesions of the jaws are not uncommon. While the majority of these represent single, sporadic lesions, histologically identical lesions are seen in association with a number of other bone lesions, as well as in certain syndromes. This
Edwards, Paul Charles
core +3 more sources
Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork [PDF]
, 2015 International audienceMCM2 is a subunit of the replicative helicase machinery shown to interact with histones H3 and H4 during the replication process through its N-terminal domain.
Almouzni, Geneviève +13 more
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H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cells
Epigenetics & ChromatinCanonical histone H3 and histone variant H3.3 are posttranslationally modified with the genomic distribution of these marks denoting different features and these modifications may influence transcription.
Benjamin J. Patty +4 more
doaj +1 more source
Ubiquitination Events That Regulate Recombination of Immunoglobulin Loci Gene Segments [PDF]
, 2014 Programed DNA mutagenesis events in the immunoglobulin (Ig) loci of developing B cells utilize the common and conserved mechanism of protein ubiquitination for subsequent proteasomal degradation to generate the required antigen-receptor diversity ...
Gerson Rothschild +2 more
core +2 more sources
HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers. [PDF]
Nucleic Acids Res, 2023 Morozov VM +8 more
europepmc +1 more source
The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. [PDF]
, 2019 The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
A Chakraborty +57 more
core +2 more sources
Role of histone variant H3.3 in neurogenesis and gliomagenesis
, 2017 Glioblastoma multiforme (GBM) (WHO classification IV) is the most common primary malignant brain tumor with a poor prognosis in both adults and children. In the last years several studies have shown that 44% of glioblastoma multiforme tumors are characterized by the same histone mutations manifested in the histone variant H3.3.
openaire +2 more sources