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Functional analysis of telomere maintenance mechanisms is more informative than immunohistochemistry for ATRX mutation interpretation in Gliomas. [PDF]

Acta Neuropathol Commun
Guerriau C, Léonce C, Carpentier C, Mokhtari K, Bielle F, Dridi-Aloulou A, Lomonte P, Meyronet D, Sanson M, Castro-Vega L, Poncet DA.   +10 more
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Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles

DNA Repair, 2022
At the most fundamental level of chromatin organization, DNA is packaged as nucleosome core particles (NCPs) where DNA is wound around a core of histone proteins. This ubiquitous sequestration of DNA within NCPs presents a significant barrier to many biological processes, including DNA repair.
Chuxuan, Li, Katelyn L, Rioux, Sarah, Delaney   +2 more
openaire   +2 more sources

Coordinated histone variant H2A.Z eviction and H3.3 deposition control plant thermomorphogenesis

New Phytologist, 2023
Summary Plants can sense temperature changes and adjust their development and morphology accordingly in a process called thermomorphogenesis. This phenotypic plasticity implies complex mechanisms regulating gene expression reprogramming in response to environmental alteration.
Fengyue Zhao, Mande Xue, Huairen Zhang, Hui Li, Ting Zhao, Danhua Jiang   +5 more
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Histone Variant H3.3 Controls Arabidopsis Fertility by Regulating Male Gamete Development

Plant And Cell Physiology, 2023
Abstract Reprograming of chromatin structures and changes in gene expression are critical for plant male gamete development, and epigenetic marks play an important role in these processes. Histone variant H3.3 is abundant in euchromatin and is largely associated with transcriptional activation.
Kunpeng Liu, Chunmei Yin, Wenjing Ye, Min Ma, Yuanda Wang, Pan Wang, Yuda Fang   +6 more
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The Role of Histone Variant H3.3 in Cortical Development

2021
The vast amount of information contained in the genome is organized and packaged by chromatin into a cell’s nucleus. This chromatin is composed of protein complexes called nucleosomes, made up of histone proteins that can regulate accessibility and functionality of the underlying DNA. Canonical histones are synthesized and deposited during S-phase in a
openaire   +2 more sources

Genes encoding a histone H3.3-like variant in Arabidopsis contain intervening sequences

Journal of Molecular Biology, 1992
Two genes encoding a particular H3 histone variant were isolated from Arabidopsis thaliana. These genes differ from the H3 genes previously cloned from Arabidopsis and other plants by several interesting properties: (1) the two genes are located close to each other; (2) their coding regions are interrupted by two or three small introns, the two closest
N, Chaubet, B, Clement, C, Gigot
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Histone variant H3.3 and its functions in reprogramming.

Yi chuan = Hereditas, 2018
Histones are a class of evolutionarily conserved nuclear proteins. Histone octamer wrapped by DNA sequence forms the nucleosome, the basic building blocks of eukaryotic chromatin. The nucleosomes keep the DNA in a condensed state, maintain the integrity of the genome, and ensure proper DNA replication, transcription, recombination and repair ...
Xing-Wei, Huang, Xiang-Rong, Cheng, Nan, Wang, Yu-Wei, Zhang, Chen, Liao, Lian-Hong, Jin, Lei, Lei   +6 more
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H2A.Z and H3.3 Histone Variants Affect Nucleosome Structure: Biochemical and Biophysical Studies

Biochemistry, 2009
Histone variants play important roles in regulation of chromatin structure and function. To understand the structural role played by histone variants H2A.Z and H3.3, both of which are implicated in transcription regulation, we conducted extensive biochemical and biophysical analysis on mononucleosomes reconstituted from either random-sequence DNA ...
Thakar, A., Gupta, P., Ishibashi, T., Finn, R., Silva-Moreno, B., Uchiyama, S., Fukui, K., Tomschik, M., Ausio, J., Zlatanova, J.   +9 more
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Transcription outcome of promoters enriched in histone variant H3.3 defined by positioning of H3.3 and local chromatin marks

Biochemical and Biophysical Research Communications, 2015
Replication-independent histone variant H3.3 is incorporated into distinct genomic regions including promoters. However topology of promoter-associated H3.3 in relation to chromatin modifications and transcriptional outcome is not known, providing no insight on any distinction between H3.3-containing active and inactive promoters.
Eivind G, Lund, Philippe, Collas, Erwan, Delbarre   +2 more
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