Results 11 to 20 of about 8,454 (206)
Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans. [PDF]
PLoS Genetics, 2006 Germline chromatin undergoes dramatic remodeling events involving histone variants during the life cycle of an organism. A universal histone variant, H3.3, is incorporated at sites of active transcription throughout the cell cycle.
Siew Loon Ooi +2 more
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The histone variant H3.3 regulates the transcription of the hepatitis B virus
Annals of Hepatology, 2021 Introduction and Objectives: About 250 million people around the world are chronically infected with the hepatitis B virus (HBV). Those people are at risk of developing hepatocellular carcinoma.
Francisca Alvarez-Astudillo +5 more
doaj +3 more sources
Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration [PDF]
Nature Communications, 2018 Incorporation of histone H3 variant H3.3 into chromatin regulates transcription. Here the authors find that H3.3 sub-variant H3mm7 is required for skeletal muscle regeneration and that H3mm7 nucleosomes are unstable and exhibit higher mobility, with ...
Akihito Harada +16 more
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Genome-wide analysis of histone H3.1 and H3.3 variants in Arabidopsis thaliana [PDF]
Proceedings of the National Academy of Sciences, 2015 Nucleosomes package eukaryotic DNA and are composed of four different histone proteins, designated H3, H4, H2A, and H2B. Histone H3 has two main variants, H3.1 and H3.3, which show different genomic localization patterns in animals.Weprofiled H3.1 and H3.
Desvoyes, Bénédicte +5 more
core +6 more sources
Histone variant H3.3 and its future prospects in cancer clinic
Journal of Radiation and Cancer Research, 2017 Histone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its
Divya Reddy, Sanjay Gupta
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HIRA defines early replication initiation zones independently of their genome compartment [PDF]
Nature CommunicationsChromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells, yet their functional interconnections remain a puzzle.
Tina Karagyozova +7 more
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Histone Variant H3.3: A versatile H3 variant in health and in disease [PDF]
Science China Life Sciences, 2016 Histones are the main protein components of eukaryotic chromatin. Histone variants and histone modifications modulate chromatin structure, ensuring the precise operation of cellular processes associated with genomic DNA. H3.3, an ancient and conserved H3 variant, differs from its canonical H3 counterpart by only five amino acids, yet it plays essential
Xiong, Chaoyang +2 more
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Cell Reports, 2016 Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells.
Antonia Piazzesi +5 more
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The Histone Variant H3.3 in Transcriptional Regulation and Human Disease. [PDF]
J Mol Biol, 2017 Histone proteins wrap around DNA to form nucleosomes, which further compact into the higher-order structure of chromatin. In addition to the canonical histones, there are also variant histones that often have pivotal roles in regulating chromatin dynamics and in the accessibility of the underlying DNA. H3.3 is the most common non-centromeric variant of
Shi L, Wen H, Shi X.
europepmc +4 more sources
Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription. [PDF]
PLoS PathogensHerpesviruses are ubiquitous pathogens that cause a wide range of disease. Upon nuclear entry, their genomes associate with histones and chromatin modifying enzymes that regulate the progression of viral transcription and outcome of infection.
Ashley P E Roberts +11 more
doaj +2 more sources