Results 21 to 30 of about 8,454 (206)
Recognizing methylated histone variant H3.3 to prevent tumors. [PDF]
Cell Res, 2014 Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription
Venkatesh S, Workman JL.
europepmc +4 more sources
Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis
Frontiers in Oncology, 2022 Canonical histone H3.1 and variant H3.3 deposit at different sites of the chromatin via distinct histone chaperones. Histone H3.1 relies on chaperone CAF-1 to mediate replication-dependent nucleosome assembly during S-phase, while H3.3 variant is ...
Ting Wen, Qiao Yi Chen
doaj +1 more source
Histone H1 binding is inhibited by histone variant H3.3 [PDF]
The EMBO Journal, 2009 Linker histones are involved in the formation of higher-order chromatin structure and the regulation of specific genes, yet it remains unclear what their principal binding determinants are. We generated a genome-wide high-resolution binding map for linker histone H1 in Drosophila cells, using DamID. H1 binds at similar levels across much of the genome,
Ulrich, Braunschweig +3 more
openaire +2 more sources
The double face of the histone variant H3.3 [PDF]
Cell Research, 2011 Histone proteins wrap DNA to form nucleosome particles that compact eukaryotic genomes while still allowing access for cellular processes such as transcription, replication and DNA repair. Histones exist as different variants that have evolved crucial roles in specialized functions in addition to their fundamental role in packaging DNA.
Szenker, Emmanuelle +2 more
openaire +3 more sources
Knockout tales: the versatile roles of histone H3.3 in development and disease
Epigenetics & Chromatin, 2023 Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease.
Rachel H. Klein, Paul S. Knoepfler
doaj +1 more source
Histone H3.3 Mutations: A Variant Path to Cancer [PDF]
Cancer Cell, 2013 A host of cancer types exhibit aberrant histone modifications. Recently, distinct and recurrent mutations in a specific histone variant, histone H3.3, have been implicated in a high proportion of malignant pediatric brain cancers. The presence of mutant H3.3 histone disrupts epigenetic posttranslational modifications near genes involved in cancer ...
Yuen, Benjamin TK, Knoepfler, Paul S
openaire +4 more sources
Nucleosome stability mediated by histone variants H3.3 and H2A.Z [PDF]
Genes & Development, 2007 Nucleosomes containing the histone variant H3.3 tend to be clustered in vivo in the neighborhood of transcriptionally active genes and over regulatory elements. It has not been clear, however, whether H3.3-containing nucleosomes possess unique properties that would affect transcription.
Chunyuan, Jin, Gary, Felsenfeld
openaire +2 more sources
Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos. [PDF]
PLoS Genetics, 2011 Upon fertilization, reprogramming of gene expression is required for embryo development. This step is marked by DNA demethylation and changes in histone variant composition.
Tomohiko Akiyama +3 more
doaj +1 more source
Arabidopsisreplacement histone variant H3.3 occupies promoters of regulated genes [PDF]
Genome Biology, 2014 Abstract Background Histone variants establish structural and functional diversity of chromatin by affecting nucleosome stability and histone-protein interactions. H3.3 is an H3 histone variant that is incorporated into chromatin outside of S-phase in various eukaryotes.
Shu Huan +7 more
openaire +5 more sources
Reciprocal intronic and exonic histone modification regions in humans. [PDF]
, 2010 While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine +3 more
core +7 more sources