Results 31 to 40 of about 8,454 (206)

Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]

, 2011
Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Arteaga-Salas, Jose M., David, Robert, Imhof, Axel, Mentele, Edith, Nicetto, Dario, Rupp, Ralph A. W., Schneider, Tobias D.   +6 more
core   +13 more sources

Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells. [PDF]

PLoS ONE, 2014
Genome-wide distribution of the majority of H2A and H3 variants (H2A, H2AX, H2AZ, macroH2A, H3.1, H3.2 and H3.3) was simultaneously investigated in mouse embryonic stem cells by chromatin immunoprecipitation sequencing.
Masashi Yukawa, Tomohiko Akiyama, Vedran Franke, Nathan Mise, Takayuki Isagawa, Yutaka Suzuki, Masataka G Suzuki, Kristian Vlahovicek, Kuniya Abe, Hiroyuki Aburatani, Fugaku Aoki   +10 more
doaj   +1 more source

Histone variant H3.3 stimulates HSP70 transcription through cooperation with HP1γ [PDF]

Nucleic Acids Research, 2011
Histone variant H3.3 and heterochromatin protein 1γ (HP1γ) are two functional components of chromatin with role in gene transcription. However, the regulations of their dynamics during transcriptional activation and the molecular mechanisms underlying their actions remain poorly understood.
Kim, Hyunjung, Heo, Kyu, Choi, Jongkyu, Kim, Kyunghwan, An, Woojin   +4 more
openaire   +2 more sources

H3.3 kinetics predicts chromatin compaction status of parental genomes in early embryos

Reproductive Biology and Endocrinology, 2021
Background After fertilization, the fusion of gametes results in the formation of totipotent zygote. During sperm-egg fusion, maternal factors participate in parental chromatin remodeling.
Shi-meng Guo, Xing-ping Liu, Li-quan Zhou   +2 more
doaj   +1 more source

Histone variant H3.3 orchestrates neural stem cell differentiation in the developing brain. [PDF]

Cell Death Differ, 2017
During the brain development, the process of neural stem cells (NSCs) proliferation and differentiation is precisely regulated. The deficiency in the embryonic brain development will cause serious developmental disorders. Epigenetic modifications play critical roles in controlling proliferation and differentiation in different types of stem cells ...
Xia W, Jiao J.
europepmc   +4 more sources

Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes [PDF]

, 2013
Death domain–associated protein (Daxx) cooperates with X-linked α-thalassaemia retardation syndrome protein (ATRX), a putative member of the sucrose non-fermentable 2 family of ATP-dependent chromatin-remodelling proteins, acting as the core ATPase ...
Andreas Mund, Badens, Baker, Berk, Berube, Blanchette, Carolin Bürck, Chatterjee, Cheng, Chinnadurai, Cuchet-Lourenco, Dallaire, Dellaire, Dobner, Drane, Everett, Flint, Frisch, Gibbons, Glass, Goldberg, Goldberg, Gostissa, Graham, Groitl, Gunther, Hancock, Harlow, Hassan, Hollenbach, Ishov, Ishov, Jin, Kahyo, Kindsmuller, Kindsmuller, Kindsmüller, Ko, Komatsu, Kosulin, Lewis, Lewis, Li, Lukashchuk, Lukashchuk, Mandy Glass, Marton, Matsumoto, Maul, McFarlane, Michaelson, Mitsudomi, Mund, Nevels, Nevins, Nevins, Niforou, Okuwaki, Orazio, Parks, Pelka, Peter Groitl, Peter Wimmer, Placek, Querido, Roger D. Everett, Ross, Rubenwolf, Sabrina Schreiner, Salomoni, Sarah Kinkley, Sarnow, Schreiner, Schreiner, Schreiner, Shenk, Si, Song, Stracker, Takahashi, Tang, Thomas Dobner, Torii, Täuber, Täuber, Ullman, White, Williams, Wilson, Wong, Wong, Xu, Xue   +92 more
core   +1 more source

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

A Developmental Requirement for HIRA-Dependent H3.3 Deposition Revealed at Gastrulation in Xenopus

Cell Reports, 2012
Discovering how histone variants that mark distinct chromatin regions affect a developmental program is a major challenge in the epigenetics field. To assess the importance of the H3.3 histone variant and its dedicated histone chaperone HIRA, we used an ...
Emmanuelle Szenker, Nicolas Lacoste, Geneviève Almouzni   +2 more
doaj   +1 more source

An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility

Nature Communications, 2020
Nucleosome turnover concomitant with incorporation of the histone variant H3.3 is a hallmark of regulatory regions in the animal genome. Here, the authors demonstrate that fast histone turnover and H3.3 incorporation defines a dynamic heterochromatin ...
Carmen Navarro, Jing Lyu, Anna-Maria Katsori, Rozina Caridha, Simon J. Elsässer   +4 more
doaj   +1 more source

ATRX: From Chromatin Remodeling to Disease. [PDF]

Genesis
ABSTRACT Chromatin remodeling proteins are evolutionarily conserved factors involved in a wide range of biological processes. In this review, we describe ATRX, a chromatin remodeling protein belonging to the SWI/SNF2 family. Its association with different protein complexes, and its roles in embryonic development, sexual differentiation, as well as ...
Magaña-Acosta M, Valadez-Graham V.
europepmc   +2 more sources