Results 51 to 60 of about 8,454 (206)
BMC Genomics, 2022 Background Toxoplasma gondii is a protozoan parasite that differentiates from acute tachyzoite stages to latent bradyzoite forms in response to environmental cues that modify the epigenome. We studied the distribution of the histone variants CenH3, H3.3,
Sheila C. Nardelli +7 more
doaj +1 more source
Histone variant H3.3 is an essential maternal factor for oocyte reprogramming. [PDF]
Proc Natl Acad Sci U S A, 2014 Significance A differentiated cell nucleus can be reprogrammed into the pluripotent state by maternal factors in ooplasm; the factors that are responsible for this reprogramming process have not yet been identified. In this paper, we show that histone variant H3.3 is one of the essential maternal factors involved in somatic nuclear ...
Wen D +9 more
europepmc +4 more sources
Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila [PDF]
, 2019 Chromatin organization influences most aspects of gene expression regulation. The linker histone H1, along with the core histones, is a key component of eukaryotic chromatin.
Pearlman, Ronald E. +7 more
core +1 more source
Inducible Deposition of the Histone Variant H3.3 in Interferon-stimulated Genes [PDF]
Journal of Biological Chemistry, 2009 The H3.3 histone variant is synthesized throughout cell cycle and deposited onto chromatin in a replication-independent manner. It is enriched in transcriptionally active regions of chromatin and is implicated in epigenetic memory. The dynamics of H3.3 deposition during transcriptional activation, however, have not been fully studied so far.
Tomohiko, Tamura +5 more
openaire +2 more sources
BMC Biology, 2022 Background SWI/SNF (BAF) chromatin remodeling complexes regulate lineage-specific enhancer activity by promoting accessibility for diverse DNA-binding factors and chromatin regulators.
Jake J. Reske +10 more
doaj +1 more source
Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma [PDF]
, 2017 Recent exciting work partly through The Cancer Genome Atlas has implicated epigenetic mechanisms including histone modifications in the development of both pediatric and adult high-grade glioma (HGG).
Kurian, Kathreena M +4 more
core +1 more source
Transcriptional activation triggers deposition and removal of the histone variant H3.3 [PDF]
Genes & Development, 2005 DNA in eukaryotic cells is packaged into nucleosomes, the structural unit of chromatin. Both DNA and bulk histones are extremely long-lived, because old DNA strands and histones are retained when chromatin duplicates. In contrast, we find that the Drosophila HSP70 genes rapidly lose histone H3 and acquire variant H3.3 histones as they are induced ...
Brian E, Schwartz, Kami, Ahmad
openaire +2 more sources
Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies
Genome Biology, 2023 Background Point mutations in histone variant H3.3 (H3.3K27M, H3.3G34R) and the H3.3-specific ATRX/DAXX chaperone complex are frequent events in pediatric gliomas.
Hsiao P. J. Voon +17 more
doaj +1 more source
New functions for an old variant: no substitute for histone H3.3 [PDF]
Current Opinion in Genetics & Development, 2010 Histone proteins often come in different variants serving specialized functions in addition to their fundamental role in packaging DNA. The metazoan histone H3.3 has been most closely associated with active transcription. Its role in histone replacement at active genes and promoters is conserved to the single histone H3 in yeast.
Elsaesser SJ, Goldberg AD, Allis CD
openaire +3 more sources
H2A.Z Acidic Patch Couples Chromatin Dynamics to Regulation of Gene Expression Programs during ESC Differentiation [PDF]
, 2013 The histone H2A variant H2A.Z is essential for embryonic development and for proper control of developmental gene expression programs in embryonic stem cells (ESCs).
A Barski +99 more
core +3 more sources