Results 61 to 70 of about 8,454 (206)

Transcriptional and Developmental Functions of the H3.3 Histone Variant in Drosophila [PDF]

Current Biology, 2009
Changes in chromatin composition accompany cellular differentiation in eukaryotes. Although bulk chromatin is duplicated during DNA replication, replication-independent (RI) nucleosome replacement occurs in transcriptionally active chromatin and during specific developmental transitions where the genome is repackaged.
Sakai, Akiko, Schwartz, Brian E., Goldstein, Sara, Ahmad, Kami   +3 more
openaire   +2 more sources

Global H3.3 dynamic deposition defines its bimodal role in cell fate transition

Nature Communications, 2018
Histone variant H3.3 is incorporated at transcriptionally active genes and is associated with active marks. Here, the authors investigate H3.3 deposition during reprogramming and find that initially H3.3 helps maintain parental cell fate and is later ...
Hai-Tong Fang, Chadi A. EL Farran, Qiao Rui Xing, Li-Feng Zhang, Hu Li, Bing Lim, Yuin-Han Loh   +6 more
doaj   +1 more source

The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin. [PDF]

PLoS Pathogens, 2013
During lytic infections, HSV-1 genomes are assembled into unstable nucleosomes. The histones required for HSV-1 chromatin assembly, however, are in the cellular chromatin. We have shown that linker (H1) and core (H2B and H4) histones are mobilized during
Kristen L Conn, Michael J Hendzel, Luis M Schang   +2 more
doaj   +1 more source

The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana

Genome Biology, 2017
Background Gene bodies of vertebrates and flowering plants are occupied by the histone variant H3.3 and DNA methylation. The origin and significance of these profiles remain largely unknown.
Heike Wollmann, Hume Stroud, Ramesh Yelagandula, Yoshiaki Tarutani, Danhua Jiang, Li Jing, Bhagyshree Jamge, Hidenori Takeuchi, Sarah Holec, Xin Nie, Tetsuji Kakutani, Steven E. Jacobsen, Frédéric Berger   +12 more
doaj   +1 more source

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation

Epigenetics & Chromatin, 2023
Background Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants into chromatin. H3.
Syed Nabeel-Shah, Jyoti Garg, Kanwal Ashraf, Renu Jeyapala, Hyunmin Lee, Alexandra Petrova, James D. Burns, Shuye Pu, Zhaolei Zhang, Jack F. Greenblatt, Ronald E. Pearlman, Jean-Philippe Lambert, Jeffrey Fillingham   +12 more
doaj   +1 more source

Tissue-specific expression of histone H3 variants diversified after species separation [PDF]

, 2015
Additional file 3: Predicted CDS of human histone H3/H4 variants, contains Table S2, which lists the CDS locus information of the predicted human histone H3 and H4 variants in an Excel ...
Akihito Harada, Hiroshi Kimura, Kazumitsu Maehara, Keiichi I. Nakayama, Masaki Matsumoto, Yasuyuki Ohkawa, Yuko Sato   +6 more
core   +4 more sources

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

Cell Reports, 2015
Histone H3.3 is a replication-independent histone variant, which replaces histones that are turned over throughout the entire cell cycle. H3.3 deposition at euchromatin is dependent on HIRA, whereas ATRX/Daxx deposits H3.3 at pericentric heterochromatin ...
Hsiao P.J. Voon, Jim R. Hughes, Christina Rode, Inti A. De La Rosa-Velázquez, Thomas Jenuwein, Robert Feil, Douglas R. Higgs, Richard J. Gibbons   +7 more
doaj   +1 more source

De novo variants in H3-3A and H3-3B are associated with neurodevelopmental delay, dysmorphic features, and structural brain abnormalities

npj Genomic Medicine, 2021
The histone H3 variant H3.3, encoded by two genes H3-3A and H3-3B, can replace canonical isoforms H3.1 and H3.2. H3.3 is important in chromatin compaction, early embryonic development, and lineage commitment.
Volkan Okur, Zefu Chen, Liesbeth Vossaert, Sandra Peacock, Jill Rosenfeld, Lina Zhao, Haowei Du, Emily Calamaro, Amanda Gerard, Sen Zhao, Jill Kelsay, Ashley Lahr, Chloe Mighton, Hillary M. Porter, Amy Siemon, Josh Silver, Shayna Svihovec, Chin-To Fong, Christina L. Grant, Jordan Lerner-Ellis, Kandamurugu Manickam, Suneeta Madan-Khetarpal, Shawn E. McCandless, Chantal F. Morel, G. Bradley Schaefer, Elizabeth M. Berry-Kravis, Ryan Gates, Natalia Gomez-Ospina, Guixing Qiu, Terry Jianguo Zhang, Zhihong Wu, Linyan Meng, Pengfei Liu, Daryl A. Scott, James R. Lupski, Christine M. Eng, Nan Wu, Bo Yuan   +37 more
doaj   +1 more source

CHD1 Regulates Deposition of Histone Variant H3.3 During Bovine Early Embryonic Development. [PDF]

Biol Reprod, 2016
The CHD family of proteins is characterized by the presence of chromodomains and SNF2-related helicase/ATPase domains, which alter gene expression by modification of chromatin structure. Chd1-null embryos arrest at the peri-implantation stage in mice.
Zhang K, Rajput SK, Wang S, Folger JK, Knott JG, Smith GW.   +5 more
europepmc   +3 more sources