Results 71 to 80 of about 8,454 (206)

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone [PDF]

, 2013
It is recognized that some mutated cancer genes contribute to the development of many cancer types, whereas others are cancer type specific. For genes that are mutated in multiple cancer classes, mutations are usually similar in the different affected ...
Amary, M.F., Amary, M.F., Baumhoer Daniel, Baumhoer Daniel, Behjati Sam, Behjati Sam, Butler, A., Butler, A., Campbell Peter J., Campbell Peter J., Cooke, S.L., Cooke, S.L., Davies, H., Davies, H., Flanagan, A.M., Flanagan, A.M., Futreal, P.A., Futreal, P.A., Goodie Victoria, Goodie Victoria, Goody, V., Goody, V., Gundem, G., Gundem, G., Halai, D., Halai, D., Hamoudi Rifat Wedge David, C., Hamoudi Rifat Wedge David, C., Jundt Gernot, Jundt Gernot, Khatri, B., Khatri, B., Martin, S., Martin, S., McLaren, S., McLaren, S., Myklebost, O., Myklebost, O., Nik-Zainal, S., Nik-Zainal, S., Pillay Nischalan, Pillay Nischalan, Presneau, Nadège, Presneau, Nadège, Robinson, B., Robinson, B., Scheipl Susanne, Scheipl Susanne, Stratton, M.R., Stratton, M.R., Tarpey Patrick Campbell Peter, J., Tarpey Patrick Campbell Peter, J., Teague, J.W., Teague, J.W., Tirabosco, R., Tirabosco, R., Van Loo Peter Hassan A Bassim, Van Loo Peter Hassan A Bassim, Wedge David C., Wedge David C.   +59 more
core   +1 more source

Meeting Summary of the 6th European Workshop on Plant Chromatin 2019 in Cologne, Germany [PDF]

, 2020
In June 2019, more than a hundred plant researchers met in Cologne, Germany, for the 6th European Workshop on Plant Chromatin (EWPC). This conference brought together a highly dynamic community of researchers with the common aim to understand how ...
Engelhorn, Julia, Farrona, Sara, Kalyanikrishna, Moreno-Romero, Jordi, Probst, Aline V., Trindade, Inês   +5 more
core   +1 more source

Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape

Cell Reports, 2013
The HIRA chaperone complex, comprised of HIRA, UBN1, and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner.
Nikolay A. Pchelintsev, Tony McBryan, Taranjit Singh Rai, John van Tuyn, Dominique Ray-Gallet, Geneviève Almouzni, Peter D. Adams   +6 more
doaj   +1 more source

The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization. [PDF]

PLoS Genetics, 2007
In many animal species, the sperm DNA is packaged with male germ line--specific chromosomal proteins, including protamines. At fertilization, these non-histone proteins are removed from the decondensing sperm nucleus and replaced with maternally provided
Emilie Bonnefoy, Guillermo A Orsi, Pierre Couble, Benjamin Loppin   +3 more
doaj   +1 more source

Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes. [PDF]

, 2017
The histone variant H2A.Z is an essential and conserved regulator of eukaryotic gene transcription. However, the exact role of this histone in the transcriptional process remains perplexing.
Bailey, Emma R, Dudek, Serena M, Dunn, Carissa J, Farris, Shannon, Saha, Ramendra N, Sarkar, Pushpita, Ward, James M, Zhao, Meilan   +7 more
core   +1 more source

Integrated high‐resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34‐mutant reveals universal TP53 abnormalities

Brain Pathology, EarlyView.
This integrated high‐resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34‐mutant expands the spectrum of associated genetic changes and underscores the presence of universal TP53 abnormalities at copy number, sequence, and protein expression level, with frequent yet largely unrecognized TP53 copy‐neutral loss of ...
Jorge A. Trejo‐Lopez, Cinthya Zepeda Mendoza, Thomas M. Kollmeyer, Kristen L. Drucker, Vanessa M. Pazdernik, Paul A. Decker, Corinne E. Praska, Jayson Hardcastle, Stephanie Smoley, Matthew Isaacson, Mallika Gandham, Surendra Dasari, Aditya Raghunathan, Caterina Giannini, Gang Zheng, Aaron Wagner, M. Beatriz Lopes, Kar‐Ming A. Fung, JoElle G. Peterson, Andreana L. Rivera, Christopher Rossi, Meggen A. Walsh, Zied Abdullaev, Kenneth Aldape, Martha Quezado, Drew Pratt, Patrick Joseph Cimino, Robert B. Jenkins, Cristiane M. Ida   +28 more
wiley   +1 more source

The Histone Variant H3.3 Marks Active Chromatin by Replication-Independent Nucleosome Assembly [PDF]

Molecular Cell, 2002
Two very similar H3 histones-differing at only four amino acid positions-are produced in Drosophila cells. Here we describe a mechanism of chromatin regulation whereby the variant H3.3 is deposited at particular loci, including active rDNA arrays. While the major H3 is incorporated strictly during DNA replication, amino acid changes toward H3.3 allow ...
Ahmad, Kami, Henikoff, Steven
openaire   +2 more sources

Chromatin remodelers and their roles in chromatin organization [PDF]

, 2012
The DNA in the eukaryotic nucleus is organized into a complex DNA-protein structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around a histone protein octamer. The nucleosomes
Strålfors, Annelie
core   +1 more source

Intrinsic specificity of a ‘core’ TIP60 acetyltransferase complex in Drosophila

The FEBS Journal, EarlyView.
The intrinsic substrate selectivity of the Drosophila TIP60‐core acetyltransferase was determined using synthetic nucleosome arrays. Targeted mass spectrometry revealed site‐specific acetylation of histones H2A, H2A.V, and H4, uncovering distinct acetylation rates and patterns across individual lysines.
Silke Krause, Marco Borsò, Marisa Müller, Axel Imhof, Zivkos Apostolou, Peter B. Becker   +5 more
wiley   +1 more source

The histone chaperone function of Daxx is dispensable for embryonic development

Cell Death and Disease, 2023
Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form a protein complex that deposits H3.3 into heterochromatic regions of the genome, including centromeres ...
Chang Sun, Yuan Qi, Natalie Fowlkes, Nina Lazic, Xiaoping Su, Guillermina Lozano, Amanda R. Wasylishen   +6 more
doaj   +1 more source