Results 81 to 90 of about 8,454 (206)

Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos [PDF]

, 2006
Upon fertilization, the gametes undergo a drastic reprogramming that includes changes in DNA methylation and histone modifications. Currently, it is not known whether replacement of the major histones by histone variants is also involved in these ...
Bannister, Andrew J., Hurd, Paul J., Kouzarides, Tony, Torres-Padilla, Maria-Elena, Zernicka-Goetz, Magdalena   +4 more
core  

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Global proteomics analysis of the response to starvation in C. elegans [PDF]

, 2015
Periodic starvation of animals induces large shifts in metabolism but may also influence many other cellular systems and can lead to adaption to prolonged starvation conditions.
Alejandro Brenes Murillo, Angelo, Angus I. Lamond, Anton Gartner, Baugh, Bin Wang, Chang, Cox, Cui, Dong, Ehsan Pourkarimi, Felix, Fredens, Grun, Handke, Henderson, Hsin, Huang, Kaeberlein, Kenyon, Larance, Larance, Larance, Liang, Long, Ly, Mark Larance, McBryant, Murphy, Narbonne, Ong, Ooi, Pourkarimi, Raharjo, Rechavi, Ritorto, Robert Kent, Sabidó, Seidel, Sheaffer, Shen, Supek, Uno, Updike, Van Gilst, Van Gilst, Vellai, Wessel, Whittle, Yankovskaya, You, Yuan, Zhao   +52 more
core   +3 more sources

Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation Through Metabolic and Synaptic Regulation

Glia, Volume 74, Issue 1, January 2026.
Astrocytic ATRX loss causes non‐cell‐autonomous neuronal hyperexcitability. Inducing ATRX deficiency in astrocytes causes selective long‐term memory deficits. Dynamic transcriptomic changes reveal metabolic and synaptic pathway dysregulation. ABSTRACT Astrocytes are increasingly recognized as active regulators of synaptic transmission and memory, yet ...
Miguel A. Pena‐Ortiz, Julia K. Sunstrum, Alireza Ghahramani, Haley McConkey, Vanessa Dumeaux, Wataru Inoue, Nathalie G. Bérubé   +6 more
wiley   +1 more source

cIMPACT‐NOW update 11: Proposal on adaptation of diagnostic criteria for IDH‐ and H3‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors

Brain Pathology, Volume 36, Issue 1, January 2026.
Abstract The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health Organization (WHO) classification.
Pieter Wesseling, David Capper, Guido Reifenberger, Chitra Sarkar, Cynthia Hawkins, Arie Perry, Bette Kleinschmidt‐DeMasters, Takashi Komori, Werner Paulus, Vani Santosh, Martin van den Bent, Michael Weller, Stefan M. Pfister, Uri Tabori, Dominique Figarella‐Branger, Brent A. Orr, David N. Louis   +16 more
wiley   +1 more source

Histone exchange sensors reveal variant specific dynamics in mouse embryonic stem cells

Nature Communications, 2023
Eviction of histones from nucleosomes and their exchange with newly synthesized or alternative variants is a central epigenetic determinant. Here, we define the genome-wide occupancy and exchange pattern of canonical and non-canonical histone variants in
Marko Dunjić, Felix Jonas, Gilad Yaakov, Roye More, Yoav Mayshar, Yoach Rais, Ayelet-Hashahar Orenbuch, Saifeng Cheng, Naama Barkai, Yonatan Stelzer   +9 more
doaj   +1 more source

Chromatin‐associated DEK proteins maintain H3K27me3 balance and coordinate developmental transitions in plants

New Phytologist, Volume 249, Issue 2, Page 930-944, January 2026.
Summary Chromatin organization and histone modifications play essential roles in regulating gene expression during development. DEK is a conserved chromatin‐associated protein implicated in DNA topology and transcriptional regulation, yet its in vivo function in plants has remained elusive.
Miyuki Nakamura, Heinrich Bente, Maria Derkacheva, Matthew Gentry, Katarina Landberg, Mattias Thelander, Eva Sundberg, Lars Hennig, Claudia Köhler   +8 more
wiley   +1 more source

Nucleosome-depleted chromatin gaps recruit assembly factors for the H3.3 histone variant [PDF]

Proceedings of the National Academy of Sciences, 2012
Most nucleosomes that package eukaryotic DNA are assembled during DNA replication, but chromatin structure is routinely disrupted in active regions of the genome. Replication-independent nucleosome replacement using the H3.3 histone variant efficiently repackages these regions, but how histones are recruited to these sites is unknown. Here,
Schneiderman, Jonathan I, Orsi, Guillermo A, Hughes, Kelly T, Loppin, Benjamin, Ahmad, Kami   +4 more
openaire   +2 more sources

An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest.

PLoS Genetics, 2012
The neural crest (NC) is a vertebrate-specific cell population that exhibits remarkable multipotency. Although derived from the neural plate border (NPB) ectoderm, cranial NC (CNC) cells contribute not only to the peripheral nervous system but also to ...
Samuel G Cox, Hyunjung Kim, Aaron Timothy Garnett, Daniel Meulemans Medeiros, Woojin An, J Gage Crump   +5 more
doaj   +1 more source