Results 261 to 270 of about 1,411,447 (295)

Histone Variants and Histone Modifications in Neurogenesis.

Trends in Cell Biology, 2020
During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS ...
Mengtian Zhang, Jinyue Zhao, Yuqing Lv, Wenwen Wang, Chao Feng, Wenzheng Zou, Libo Su, Jianwei Jiao   +7 more
semanticscholar   +3 more sources

Histone Variants

Methods in Molecular Biology, 2018
Guillermo A. Orsi, Geneviève Almouzni
semanticscholar   +2 more sources

Monoclonal Autoantibodies Recognizing Histone Variants

Immunological Investigations, 1988
Balb/c mice were immunized with affinity purified Ro(SS-A) from human origin in order to allow the preparation of monoclonal anti-Ro(SS-A) antibodies. After fusion of mouse myeloma cells (line Sp2/0 A914) with spleen cells from one of these mice, anti-Ro(SS-A) monoclonals were not obtained, but, instead, two IgM producing hybridomas reactive with ...
van Hemert, Formijn J., van Dam, Alje P., Jonk, Luigi J. C., Olivier, H. J., Destrée, J. T., Smeenk, Ruud J. T.   +5 more
openaire   +3 more sources

Nucleosome dynamics and histone variants

Essays in Biochemistry, 2010
In eukaryotes, DNA is organized into chromatin, a dynamic structure that enables DNA to be accessed for processes such as transcription, replication and repair. To form, maintain or alter this organization according to cellular needs, histones, the main protein component of chromatin, are deposited, replaced, exchanged and post-translationally modified.
Dominique, Ray-Gallet, Geneviève, Almouzni   +1 more
openaire   +2 more sources

Histone variants and epigenetic inheritance

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012
Nucleosome particles, which are composed of core histones and DNA, are the basic unit of eukaryotic chromatin. Histone modifications and histone composition determine the structure and function of the chromatin; this genome packaging, often referred to as "epigenetic information", provides additional information beyond the underlying genomic sequence ...
Gang, Yuan, Bing, Zhu
openaire   +2 more sources

Histone variants meet their match

Nature Reviews Molecular Cell Biology, 2005
A fascinating aspect of how chromatin structure impacts on gene expression and cellular identity is the transmission of information from mother to daughter cells, independently of the primary DNA sequence. This epigenetic information seems to be contained within the covalent modifications of histone polypeptides and the distinctive characteristics of ...
Kavitha, Sarma, Danny, Reinberg
openaire   +2 more sources

Histone variants and lipid metabolism

Biochemical Society Transactions, 2014
Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism.
Borghesan, M., Mazzoccoli, G., Sheedfar, F., Oben, J., Pazienza, V., Vinciguerra, M.   +5 more
openaire   +4 more sources

Histone variants in plant transcriptional regulation.

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017
Chromatin based organization of eukaryotic genome plays a profound role in regulating gene transcription. Nucleosomes form the basic subunits of chromatin by packaging DNA with histone proteins, impeding the access of DNA to transcription factors and RNA polymerases.
Danhua Jiang, F. Berger
semanticscholar   +3 more sources

Histone variants: nuclear function and disease.

Current Opinion in Genetics & Development, 2016
Histone variants have emerged as important contributors to the regulation of chromatin structure and therefore of almost all DNA-based processes. Hence, these specialized proteins play important roles in transcriptional regulation, cell cycle progression, DNA repair, chromatin stability, chromosome segregation and apoptosis.
Lisa-Maria Zink, S. Hake
semanticscholar   +3 more sources

Histone variants and histone modifications: A structural perspective

Biochemistry and Cell Biology, 2001
In this review, we briefly analyze the current state of knowledge on histone variants and their posttranslational modifications. We place special emphasis on the description of the structural component(s) defining and determining their functional role. The information available indicates that this histone "variability" may operate at different levels:
J, Ausió, D W, Abbott, X, Wang, S C, Moore   +3 more
openaire   +2 more sources