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The modification and variants of histone
Molecular Biology, 2007The modification of histone plays a crucial role in regulating chromatin states that conserve transcription programs and provide a mechanism for chromatin states to be maintained as cells proliferate. A large number of factors and protein complexes are now known to be involved in regulating the dynamic states of the modification and variants of histone.
Changjun, Mu +2 more
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The Structural Determinants behind the Epigenetic Role of Histone Variants
Genes, 2015 Histone variants are an important part of the histone contribution to chromatin epigenetics. In this review, we describe how the known structural differences of these variants from their canonical histone counterparts impart a chromatin signature ...
Juan Ausió, Manjinder S Cheema
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Analysis of Histones and Histone Variants in Plants
2011Histone proteins are the major protein components of chromatin - the physiologically relevant form of the genome (or epigenome) in all eukaryotic cells. For many years, histones were considered passive structural components of eukaryotic chromatin. In recent years, it has been demonstrated that dynamic association of histones and their variants to the ...
Ila, Trivedi +7 more
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Histone Variants in Development and Diseases
Journal of Genetics and Genomics, 2013Eukaryotic genomic DNA is highly packaged into chromatin by histones to fit inside the nucleus. Other than the bulk packaging role of canonical histones with an expression peak at S phase and replication-coupled deposition, different histone variants have evolved distinct regulatory mechanisms for their expression, deposition and functional ...
Ping, Chen, Jicheng, Zhao, Guohong, Li
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ASSEMBLY OF VARIANT HISTONES INTO CHROMATIN
Annual Review of Cell and Developmental Biology, 2005Chromatin can be differentiated by the deposition of variant histones at centromeres, active genes, and silent loci. Variant histones are assembled into nucleosomes in a replication-independent manner, in contrast to assembly of bulk chromatin that is coupled to replication.
Steven, Henikoff, Kami, Ahmad
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Histone variants and epigenetic inheritance
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012Nucleosome particles, which are composed of core histones and DNA, are the basic unit of eukaryotic chromatin. Histone modifications and histone composition determine the structure and function of the chromatin; this genome packaging, often referred to as "epigenetic information", provides additional information beyond the underlying genomic sequence ...
Gang, Yuan, Bing, Zhu
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2018
In eukaryotes, the genome is organized into a complex nucleoprotein structure called chromatin. Despite the simplicity of its monomer, DNA and two copies of four histones, the existence of histone variants opens possibilities of multiple chromatin landscapes and fine-tune regulation of molecular mechanisms for the regulation of gene expression and ...
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In eukaryotes, the genome is organized into a complex nucleoprotein structure called chromatin. Despite the simplicity of its monomer, DNA and two copies of four histones, the existence of histone variants opens possibilities of multiple chromatin landscapes and fine-tune regulation of molecular mechanisms for the regulation of gene expression and ...
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Histone variants meet their match
Nature Reviews Molecular Cell Biology, 2005A fascinating aspect of how chromatin structure impacts on gene expression and cellular identity is the transmission of information from mother to daughter cells, independently of the primary DNA sequence. This epigenetic information seems to be contained within the covalent modifications of histone polypeptides and the distinctive characteristics of ...
Kavitha, Sarma, Danny, Reinberg
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[Histone variants and histone exchange].
Yi chuan = Hereditas, 2009Histones, as the basic components of nucleosome, are essential to chromatin structure and function. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants' tails.
Nan, Wu, Jian-Fang, Gui
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H 1 histone and histone variants in Trypanosoma cruzi
Experimental Cell Research, 1988Trypanosoma cruzi chromatin is not condensed in chromosomes during mitosis. In previous studies a characteristic H 1 was not found in SDS or in acid-urea-PAGE. Consequently, it was proposed that the particular behavior of T. cruzi chromatin in dividing cells was due to the absence of an H 1 histone. In the present work, histones from this parasite were
G C, Toro, N, Galanti
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