Results 231 to 240 of about 836,867 (274)
Advanced Science, EarlyView.This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li +8 more
wiley +1 more source
The Structural Determinants behind the Epigenetic Role of Histone Variants [PDF]
Genes, 2015 Histone variants are an important part of the histone contribution to chromatin epigenetics. In this review, we describe how the known structural differences of these variants from their canonical histone counterparts impart a chromatin signature ...
Juan Ausió
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Histone Variants and Histone Modifications in Neurogenesis
Trends in Cell Biology, 2020During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS ...
Mengtian Zhang +7 more
openaire +2 more sources
Histone variants and cellular plasticity [PDF]
Trends in Genetics, 2015 The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular signals and the DNA is the chromatin, a dynamic nucleoprotein complex that helps to mediate gene regulation.
Catherine Dulac
exaly +5 more sources
The modification and variants of histone
Molecular Biology, 2007The modification of histone plays a crucial role in regulating chromatin states that conserve transcription programs and provide a mechanism for chromatin states to be maintained as cells proliferate. A large number of factors and protein complexes are now known to be involved in regulating the dynamic states of the modification and variants of histone.
Changjun, Mu +2 more
openaire +2 more sources
Histone variants meet their match
Nature Reviews Molecular Cell Biology, 2005A fascinating aspect of how chromatin structure impacts on gene expression and cellular identity is the transmission of information from mother to daughter cells, independently of the primary DNA sequence. This epigenetic information seems to be contained within the covalent modifications of histone polypeptides and the distinctive characteristics of ...
Danny Reinberg, Kavitha Sarma
exaly +3 more sources
Analysis of Histones and Histone Variants in Plants
2011Histone proteins are the major protein components of chromatin - the physiologically relevant form of the genome (or epigenome) in all eukaryotic cells. For many years, histones were considered passive structural components of eukaryotic chromatin. In recent years, it has been demonstrated that dynamic association of histones and their variants to the ...
Ila, Trivedi +7 more
openaire +2 more sources
Histone Variants in Development and Diseases
Journal of Genetics and Genomics, 2013Eukaryotic genomic DNA is highly packaged into chromatin by histones to fit inside the nucleus. Other than the bulk packaging role of canonical histones with an expression peak at S phase and replication-coupled deposition, different histone variants have evolved distinct regulatory mechanisms for their expression, deposition and functional ...
Ping, Chen, Jicheng, Zhao, Guohong, Li
openaire +2 more sources
ASSEMBLY OF VARIANT HISTONES INTO CHROMATIN
Annual Review of Cell and Developmental Biology, 2005Chromatin can be differentiated by the deposition of variant histones at centromeres, active genes, and silent loci. Variant histones are assembled into nucleosomes in a replication-independent manner, in contrast to assembly of bulk chromatin that is coupled to replication.
Steven, Henikoff, Kami, Ahmad
openaire +2 more sources
The double face of the histone variant H3.3 [PDF]
Cell Research, 2011 Histone proteins wrap DNA to form nucleosome particles that compact eukaryotic genomes while still allowing access for cellular processes such as transcription, replication and DNA repair. Histones exist as different variants that have evolved crucial roles in specialized functions in addition to their fundamental role in packaging DNA.
Geneviève Almouzni +1 more
exaly +4 more sources