Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila [PDF]
, 2019 Chromatin organization influences most aspects of gene expression regulation. The linker histone H1, along with the core histones, is a key component of eukaryotic chromatin.
Pearlman, Ronald E. +7 more
core +1 more source
H2A Variants in Arabidopsis: Versatile Regulators of Genome Activity
Plant Communications, 2020 The eukaryotic nucleosome prevents access to the genome. Convergently evolving histone isoforms, also called histone variants, form diverse families that are enriched over distinct features of plant genomes.
Bingkun Lei, Frédéric Berger
doaj +1 more source
Dynamic deposition of histone variant H3.3 accompanies developmental remodeling of the Arabidopsis transcriptome. [PDF]
PLoS Genetics, 2012 In animals, replication-coupled histone H3.1 can be distinguished from replication-independent histone H3.3. H3.3 variants are enriched at active genes and their promoters. Furthermore, H3.3 is specifically incorporated upon gene activation.
Heike Wollmann +5 more
doaj +1 more source
Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]
, 2018 Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
core +1 more source
Histone variant innovation in a rapidly evolving chordate lineage
BMC Evolutionary Biology, 2011 Background Histone variants alter the composition of nucleosomes and play crucial roles in transcription, chromosome segregation, DNA repair, and sperm compaction.
Jansen Pascal WTC +6 more
doaj +1 more source
The European Zoological Journal, 2021 In this work, a polymorphic variability of Muscovy duck histone H1.c’ is presented along with a link of its allelic variants with an extent of ADP (Adenosine Diphosphate)-ribosylation of histone H1 non-allelic subtypes.
Andrzej Kowalski
doaj +1 more source
A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases. [PDF]
, 2013 We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53.
Agrawal, Sumit K +17 more
core +3 more sources
Histone H1 binding is inhibited by histone variant H3.3 [PDF]
The EMBO Journal, 2009 Linker histones are involved in the formation of higher-order chromatin structure and the regulation of specific genes, yet it remains unclear what their principal binding determinants are. We generated a genome-wide high-resolution binding map for linker histone H1 in Drosophila cells, using DamID. H1 binds at similar levels across much of the genome,
Ulrich, Braunschweig +3 more
openaire +2 more sources
Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]
, 2020 Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A. +11 more
core +1 more source
Global turnover of histone post-translational modifications and variants in human cells
Epigenetics & Chromatin, 2010 Background Post-translational modifications (PTMs) on the N-terminal tails of histones and histone variants regulate distinct transcriptional states and nuclear events.
Zee Barry M +3 more
doaj +1 more source